Asymptomatic Middle East Respiratory Syndrome Coronavirus Infection in Rabbits
Asymptomatic Middle East Respiratory Syndrome Coronavirus Infection in Rabbits
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DOI：
10.1128/jvi.00661-15
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发表时间：
2015-06-01
影响因子：
5.4
通讯作者：
Osterhaus, Albert D. M. E.
中科院分区：
文献类型：
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作者：
Haagmans, Bart L.;van den Brand, Judith M. A.;Osterhaus, Albert D. M. E.
中东呼吸综合征冠状病毒（MERS-CoV）感染小动物物种的能力可能会受到限制，因为小鼠、雪貂和仓鼠对MERS-CoV感染具有抵抗力。我们给兔子接种MERS CoV。虽然在肺中检测到病毒，但未观察到显著的组织病理学变化或临床症状。然而，感染性病毒从上呼吸道排出，表明MERS-CoV在某些动物物种中的潜在传播途径。
The ability of Middle East respiratory syndrome coronavirus (MERS-CoV) to infect small animal species may be restricted given the fact that mice, ferrets, and hamsters were shown to resist MERS-CoV infection. We inoculated rabbits with MERS-CoV. Although virus was detected in the lungs, neither significant histopathological changes nor clinical symptoms were observed. Infectious virus, however, was excreted from the upper respiratory tract, indicating a potential route of MERS-CoV transmission in some animal species.