Inverse correlation between the expression of bcl-2 and p53 proteins in primary gastric lymphoma
Inverse correlation between the expression of bcl-2 and p53 proteins in primary gastric lymphoma
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DOI：
10.1016/s0046-8177(96)90061-1
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发表时间：
1996-03-01
期刊：
影响因子：
3.3
通讯作者：
Tsuneyoshi, M
中科院分区：
文献类型：
--
作者：
Nakamura, S;Akazawa, K;Tsuneyoshi, M
研究了212例原发性胃淋巴瘤患者经福尔马林固定、石蜡包埋手术标本中bcl-2和p53蛋白的免疫组织化学表达。145例（68%）标本中表达Bcl-2蛋白。在179例粘膜相关淋巴组织b细胞淋巴瘤（MALT）中，bcl-2阳性随组织学分级的提高而显著降低；bcl-2在93%的低级别肿瘤、88%的混合级别肿瘤（低级别伴局灶性高级别成分）和44%的高级别肿瘤中表达（Cochran线性趋势检验；P < 0.001）。212例患者中有43例（20%）检测到P53蛋白表达。在b细胞MALT淋巴瘤中，p53阳性随着组织学分级的增加而显著升高；p53在6%的低级别肿瘤、12%的混合级别肿瘤和31%的高级别肿瘤中表达（Cochran's线性趋势检验；P < 0.001）。在所有212例淋巴瘤（Gamma = -0.531, P < 0.05）和所有179例b细胞MALT淋巴瘤（Gamma = -0.671, P < 0.01）中，bcl-2和p53的表达呈负相关。虽然bcl-2表达与患者生存无相关性，但p53阳性患者的预后明显差于p53阴性患者（log-rank检验；P < 0.05）。这些结果表明，bcl-2和p53的表达可能与原发性胃淋巴瘤从低级别肿瘤向高级别肿瘤的转变有关。(C) 1996年，W.B. Saunders Company
The immunohistochemical expression of bcl-2 and p53 proteins was evaluated in formalin-fixed, paraffin-embedded surgical specimens from 212 patients with primary gastric lymphoma. bcl-2 protein was found to be expressed in 145 specimens (68%). Among the 179 specimens with B-cell lymphoma of mucosa-associated lymphoid tissue (MALT), bcl-2 positivity decreased significantly as the histological grade advanced; bcl-2 was expressed in 93% of low-grade tumors, 88% of mixed-grade (low-grade with a focal high-grade component) tumors, and 44% of high-grade tumors (Cochran's linear trend test; P < .001). p53 protein expression was detected in 43 of 212 cases (20%). Among the B-cell MALT lymphomas, p53 positivity increased significantly as the histological grade advanced; p53 was expressed in 6% of low-grade tumors, 12% of mixed-grade tumors, and 31% of high-grade tumors (Cochran's linear trend test; P < .001). An inverse correlation was observed between the expression of bcl-2 and p53 in all 212 lymphomas (Gamma = -0.531; P < .05) as well as in all 179 B-cell MALT lymphomas (Gamma = -0.671; P < .01). Although the bcl-2 expression did not correlate with the patient survival, the p53 positive cases showed a significantly poorer prognosis compared with the p53 negative cases (log-rank test; P < .05). These results suggest that the expression of bcl-2 and p53 may, therefore, be associated with the transition from low-grade to high-grade tumors in primary gastric lymphoma. (C) 1996 by W.B. Saunders Company