Interstitial Pneumonia in Psoriasis.
Interstitial Pneumonia in Psoriasis.
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DOI：
10.1016/j.mayocpiqo.2018.07.006
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发表时间：
2018-12-01
期刊：
影响因子：
--
通讯作者：
Kuwano, Kazuyoshi
中科院分区：
文献类型：
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作者：
Kawamoto, Hironori;Hara, Hiromichi;Kuwano, Kazuyoshi
目的：探讨银屑病与间质性肺炎（IP）之间的关系。 患者和方法：我们回顾性分析了2008年6月1日至2017年6月30日接受生物制剂治疗的银屑病患者的临床资料。 392 名患者在治疗前进行了胸部计算机断层扫描。对这些患者的临床特征和影像学结果进行了评估。结果：392 例银屑病患者中，8 例（2%）检测到 IP。下肺区双侧磨玻璃样和/或不规则线性（网状）混浊是最常见的胸部计算机断层扫描发现。 8 名 IP 患者中的 5 名接受了抗白细胞介素 (IL) 12/IL-23 或 IL-17 抗体治疗，导致 IP 活性降低或稳定。结论：需要全身治疗的银屑病患者中有 2% 检测到间质性肺炎。双侧下叶毛玻璃样和/或不规则线状（网状）混浊是 IP 银屑病的特征。 IL-23/IL-17轴可能在银屑病IP的发病机制中发挥重要作用。
OBJECTIVE: To investigate the relationship between psoriasis and interstitial pneumonia (IP).PATIENTS AND METHODS: We analyzed the clinical data of patients with psoriasis treated with biologic agents from June 1, 2008, to June 30, 2017, retrospectively. Chest computed tomography was performed in 392 patients before treatment. The clinical characteristics and radiographic findings of these patients were evaluated.RESULTS: Of the 392 patients with psoriasis, IP was detected in 8 patients (2%). Bilateral ground-glass and/or irregular linear (reticular) opacity in the lower lung zone was the most common chest computed tomography finding. Five of the 8 patients with IP were treated with anti-interleukin (IL) 12/IL-23 or IL-17 antibodies, leading to decreased or stable IP activity.CONCLUSION: Interstitial pneumonia was detected in 2% of patients with psoriasis who needed systemic treatments. Ground-glass and/or irregular linear (reticular) opacity in the bilateral lower lobes was characteristic of IP with psoriasis. The IL-23/IL-17 axis may play important roles in the pathogenesis of IP in psoriasis.