Low metacarpal index predicts hip fracture -: A prospective population study of 3,561 subjects with 15 years of follow-up
Low metacarpal index predicts hip fracture -: A prospective population study of 3,561 subjects with 15 years of follow-up
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DOI：
10.1080/17453670610045632
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发表时间：
2006-02-01
影响因子：
3.7
通讯作者：
Kröger, H
中科院分区：
文献类型：
--
作者：
Haara, M;Heliövaara, M;Kröger, H
研究背景掌骨指数(MCI)是由手部X线片测量的骨皮质厚度与骨直径的比值，被认为是评估骨量和骨质疏松性骨折风险的指标。我们研究了MCI预测髋部骨折的能力。方法从1978-80年间8,000名30岁或以上的芬兰人中抽取3,561名受试者拍摄手部X光片，并测定MCI。结果高年龄、低体重指数、高身高和基线时吸烟与低MCI显著相关。低MCI是髋部骨折的有力预测因素。在调整了所有潜在的混杂因素后，MCI每减少一个标准差(0.1)发生髋部骨折的相对风险为1.5(95%可信区间1.2-1.8)。解释低MCI与已知的骨质疏松危险因素相关，并预测髋部骨折。由于手部X光片很容易以低成本获得，MCI的测量可以作为一种替代方法来寻找具有高髋部骨折风险的骨质疏松症患者。
Background Metacarpal index (MCI), measured from hand radiographs as the ratio between combined cortical thickness and bone diameter, has been suggested for assessment of bone mass and risk of osteoporotic fracture. We studied MCI for its ability to predict hip fractures.Methods Hand radiographs were taken and MCI determined in 3,561 subjects from a representative population sample of 8,000 Finns who were 30 years of age or over in 1978-80. Record linkage to the National Hospital Discharge Register identified 117 subjects who had been hospitalized for primary treatment of hip fracture by the end of 1994.Results High age, low body mass index, tall stature and smoking at baseline showed, independently of each other, significant associations with low MCI. Low MCI was a strong predictor of hip fracture. When adjusted for all potential confounding factors, the relative risk of hip fracture per decrement of MCI by one standard deviation (0.1) was 1.5 (95% CI 1.2-1.8).Interpretation Low MCI is associated with known risk factors of osteoporosis and predicts hip fracture. Since hand radiographs are easily available at low cost, measurements of MCI can be used as an alternative approach to find osteoporotic individuals with a high risk of hip fracture.