The relationship between the expression of the glucocorticoid receptor in biopsied colonic mucosa and the glucocorticoid responsiveness of ulcerative colitis patients
The relationship between the expression of the glucocorticoid receptor in biopsied colonic mucosa and the glucocorticoid responsiveness of ulcerative colitis patients
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DOI：
10.1016/j.clim.2009.07.006
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发表时间：
2009-11-01
影响因子：
8.6
通讯作者：
Yamakawa, Mitsunori
中科院分区：
文献类型：
--
作者：
Fujishima, Sho-ichiro;Takeda, Hiroaki;Yamakawa, Mitsunori
本研究的目的是阐明活检结肠粘膜中表达糖皮质激素受体（GR）α和β的浸润细胞的频率与溃疡性结肠炎（UC）患者的糖皮质激素（GC）反应性之间的关系。活动性 UC 患者 (n=38) 分为 GC 敏感组和 GC 耐药组。 GC抵抗组中GR beta(+)细胞显着高于GC敏感组和对照组。 GR α mRNA 在所有 UC 患者中表达，白色 GR β mRNA 在 GC 敏感组中仅 1 名患者（n = 6）和 GC 耐药组中 7 名患者（n = 8）中表达。经常观察到 GR beta 和 CD4 或 CD19 双阳性细胞。 GC敏感组的Foxp3(+)细胞计数显着高于GC抵抗组，但未观察到双倍Foxp3(+)GR beta(+)细胞。这些结果表明，CC 疗法的敏感性可能可以通过 GR beta 和 Foxp3 的免疫染色活检标本来预测。 (C) 2009 Elsevier Inc. 保留所有权利。
The objective of this study was to clarify the relationship between the frequency of infiltrating cells expressing the glucocorticoid receptors (GR) alpha and beta in biopsied colonic mucosa and the glucocorticoid (GC) responsiveness of ulcerative colitis (UC) patients. Active UC patients (n=38) were divided into GC-sensitive and GC-resistant groups. GR beta(+) cells were significantly higher in the GC-resistant group than in the GC-sensitive and control groups. GR alpha mRNA was expressed in all UC patients, white GR beta mRNA was expressed in only 1 patient in the GC-sensitive group (n=6) and 7 patients in the GC-resistant group (n=8). Double-positive cells for GR beta and CD4 or CD19 were frequently observed. The Foxp3(+) cell count was significantly higher in the GC-sensitive group than in the GC-resistant group, but double Foxp3(+)GR beta(+) cells were not observed. These results indicated that the sensitivity of CC therapy could probably be predicted by immunostaining biopsy specimens for GR beta and Foxp3. (C) 2009 Elsevier Inc. All rights reserved.