Mycobacterium tuberculosis infection among persons who inject drugs in San Diego, California
Mycobacterium tuberculosis infection among persons who inject drugs in San Diego, California
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DOI：
10.5588/ijtld.16.0434
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发表时间：
2017-04-01
影响因子：
4
通讯作者：
Garfein, R. S.
中科院分区：
文献类型：
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作者：
Armenta, R. F.;Collins, K. M.;Garfein, R. S.
背景技术背景：注射吸毒者（PWID）可能因注射吸毒而增加结核分枝杆菌感染和潜伏性结核感染（LTBI）再激活的风险。目的：确定M.方法：年龄>= 18岁的PWID进行标准化访谈和血清学测试，使用干扰素-γ释放测定法（IGRA）检测LTBI，并使用快速即时检测法检测人类免疫缺陷病毒（HIV）和丙型肝炎病毒（HCV）感染。与M.结核病感染，确定使用多变量log-binomial regression.结果：共有500名参与者符合资格标准。平均年龄为43.2岁（标准差11.6）;大多数受试者为白色（52%）或西班牙裔（30.8%）和男性（75%）。总体而言，86.7%的人表示曾经去过墨西哥。M的流行。结核病感染率为23.6%，合并HIV感染率为0.8%，合并HCV感染率为81.7%。几乎所有参与者（95%）以前都进行过M。结核病; 7.6%的人以前被告知他们被感染。M.结核病感染与西班牙裔、有较长的注射史、HCV检测阳性以及正确报告患有“睡眠”结核病的人不会感染他人独立相关。美国/墨西哥边境地区PWID中的结核病感染。
BACKGROUND: Persons who inject drugs (PWID) might be at increased risk for Mycobacterium tuberculosis infection and reactivation of latent tuberculous infection (LTBI) due to their injection drug use. OBJECTIVES: To determine prevalence and correlates of M. tuberculosis infection among PWID in San Diego, California, USA.METHODS: PWID aged >= 18 years underwent standardized interviews and serologic testing using an interferon-gamma release assay (IGRA) for LTBI and rapid point-of-care assays for human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections. Independent correlates of M. tuberculosis infection were identified using multivariable log-binomial regression.RESULTS: A total of 500 participants met the eligibility criteria. The mean age was 43.2 years (standard deviation 11.6); most subjects were White (52%) orHispanic (30.8%), and male (75%). Overall, 86.7% reported having ever traveled to Mexico. Prevalence of M. tuberculosis infection was 23.6%; 0.8% were co-infected with HIV and 81.7% were co-infected with HCV. Almost all participants (95%) had been previously tested for M. tuberculosis; 7.6% had been previously told they were infected. M. tuberculosis infection was independently associated with being Hispanic, having longer injection histories, testing HCV-positive, and correctly reporting that people with 'sleeping' TB cannot infect others.CONCLUSIONS: Strategies are needed to increase awareness about and treatment for M. tuberculosis infection among PWID in the US/Mexico border region.