Design and synthesis of β-methoxyacrylate analogues via click chemistry and biological evaluations
Design and synthesis of β-methoxyacrylate analogues via click chemistry and biological evaluations
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DOI：
10.1016/j.bmcl.2007.01.021
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发表时间：
2007-04-01
影响因子：
2.7
通讯作者：
Abrams, Suzanne R.
中科院分区：
文献类型：
--
作者：
Chen, Hao;Taylor, Janet L.;Abrams, Suzanne R.
通过Cu(I)催化的1,3-偶极炔-叠氮偶联反应或“点击化学”，设计并合成了潜在的抗真菌三唑修饰对甲氧基丙烯酸酯类似物库。随后的生物学筛选显示，一些化合物对病原菌表现出低至中等的抗真菌活性和低的植物毒性。(c) 2007 Elsevier Ltd.版权所有。
A library of potential antifungal triazole-modified P-methoxyacrylate analogues was designed and synthesized via a Cu(I)-catalyzed 1,3-dipolar alkyne-azide coupling reaction or 'click chemistry'. Subsequent biological screening revealed that some compounds displayed low to moderate antifungal activity toward pathogenic fungi and low phytotoxicity. (c) 2007 Elsevier Ltd. All rights reserved.