Interference between Streptococcus pneumoniae and Staphylococcus aureus:: In vitro hydrogen peroxide-mediated killing by Streptococcus pneumoniae
Interference between Streptococcus pneumoniae and Staphylococcus aureus:: In vitro hydrogen peroxide-mediated killing by Streptococcus pneumoniae
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DOI：
10.1128/jb.00317-06
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发表时间：
2006-07-01
影响因子：
3.2
通讯作者：
Lipsitch, Marc
中科院分区：
文献类型：
--
作者：
Regev-Yochay, Gili;Trzcinski, Krzysztof;Lipsitch, Marc
过氧化氢介导肺炎链球菌对金黄色葡萄球菌的杀菌活性。过氧化氢酶消除了这种活性。厌氧生长的肺炎球菌或遗传上缺乏丙酮酸氧化酶（SpxB）的肺炎球菌不具有杀菌作用，非肺炎球菌链球菌也不具有杀菌作用。这些结果为流行病学研究中观察到的种间干扰提供了可能的机制解释。
The bactericidal activity of Streptococcus pneumoniae toward Staphylococcus aureus is mediated by hydrogen peroxide. Catalase eliminated this activity. Pneumococci grown anaerobically or genetically lacking pyruvate oxidase (SpxB) were not bactericidal, nor were nonpneumococcal streptococci. These results provide a possible mechanistic explanation for the interspecies interference observed in epidemiologic studies.