Bioaccumulation and biomarker responses of cubic and octahedral Cu2O micro/nanocrystals in Daphnia magna
Bioaccumulation and biomarker responses of cubic and octahedral Cu2O micro/nanocrystals in Daphnia magna
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DOI：
10.1016/j.watres.2012.08.019
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发表时间：
2012-11-15
期刊：
影响因子：
12.8
通讯作者：
Guo, Lin
中科院分区：
文献类型：
--
作者：
Fan, Wenhong;Shi, Zhiwei;Guo, Lin
具有特定尺寸、形状和几何形状的纳米材料的可控制备已经取得了很大的进展。然而，这种结构上的变化如何潜在地影响金属纳米颗粒对水生生物的生物利用度和毒性仍然是未知的。本文报道了两种不同形状（立方和八面体）和晶型（{100}和{111}）的Cu 2 O微/纳米晶（micro/nano-Cu 2 O）的不同行为。生物富集，半致死浓度，和生物标志物的大型蚤暴露于两个微/纳米晶体的反应也进行了研究。结果表明，在不同浓度下，D.随着微/纳米Cu_2O浓度的增加，magna逐渐增加。两种晶体对D的铜积累略有差异。magna的生物标志物反应和毒性。Magna也有显著差异。八面体Cu 2 O微/纳米晶对D. Magna与立方微米/纳米晶体相比，可能是因为与铜矿的{100}晶面相比，{111}晶面具有更高的表面活性。食物摄入是微/纳米晶体进入生物体的主要途径，因此基于微/纳米晶体在体内的溶解行为来确定毒性。(C)2012爱思唯尔有限公司保留所有权利。
Great progress has been made in the controlled fabrication of nanomaterials with given sizes, shapes, and geometries. However, how such changes in structure potentially affect the bioavailability and toxicity of metal nanoparticles to aquatic organisms remains mostly unknown. The present study reports the different behaviors of two types of Cu2O micro/nanocrystals (micro/nano-Cu2O) with different shapes (cubic and octahedral) and crystallographies (with exposed surfaces as {100} or {111}). The bioaccumulation, median lethal concentration, and biomarker responses of Daphnia magna exposed to the two micro/nanocrystals are also investigated. The Cu accumulation, production of metallothionein (MT), and inhibition ratio of D. magna increased gradually with increasing micro/nano-Cu2O concentration. The two crystals showed slight Cu accumulation differences toward D. magna, and their biomarker responses and toxicities to D. magna differed significantly as well. The octahedral Cu2O micro/nanocrystals were more toxic to D. magna compared with the cubic micro/nanocrystals probably because of the higher surface activities of the {111} facets compared with those of the {100} facets for cuprites. Food ingestion was the main entry pathway of the micro/nanocrystals into organisms, and toxicity was consequently determined based on the dissolution behavior of the micro/nanocrystals in vivo. (C) 2012 Elsevier Ltd. All rights reserved.