Nomograms incorporating primary tumor response at mid-radiotherapy to predict survival in locoregionally advanced nasopharyngeal carcinoma
Nomograms incorporating primary tumor response at mid-radiotherapy to predict survival in locoregionally advanced nasopharyngeal carcinoma
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DOI：
10.1002/hed.27404
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发表时间：
2023-05-19
影响因子：
2.9
通讯作者：
Yang，Kunyu
中科院分区：
文献类型：
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作者：
Liu，Xixi;Huang，Jing;Yang，Kunyu
背景尚未建立一个包含中期放疗（mid-RT）肿瘤反应的诺模图来预测局部晚期鼻咽癌（LA-NPC）的预后。方法本研究回顾性分析了583例LA-NPC患者，他们在中期RT接受了磁共振成像扫描。结果发现中期RT时原发性肿瘤（PT）缓解可预测无病生存期（DFS）和总生存期（OS）。将来自多变量分析的预测DFS和OS的独立因素组装成有（列线图Amid-RT和Bmid-RT）或无（列线图Abbaseline和Bbaseline）PT应答的列线图。内部验证显示这些列线图在区分方面具有良好的性能：列线图Amid‐ RT的C‐统计量= 0.761，列线图Bmid‐RT的C ‐统计量= 0.809，这表明其区分性能优于（C-统计量：0.755）诺模图基线和（C-统计量：0.798）诺模图B基线（Z-统计量= 2.476，p <0.05; Z-统计量= 1.971，p < 0.05）。
BackgroundA nomogram that incorporates tumor response at mid‐radiotherapy (mid‐RT) to predict the prognosis of locoregionally advanced nasopharyngeal carcinoma (LA‐NPC) has not been established.MethodsThis study retrospectively reviewed 583 patients with LA‐NPC who underwent magnetic resonance imaging scans at mid‐RT (the fourth week of RT) between 2015 and 2019.ResultsPrimary tumor (PT) response at mid‐RT was found to predict disease‐free survival (DFS) and overall survival (OS). Independent factors from multivariable analysis to predict DFS and OS were assembled into nomograms with (nomograms Amid‐RTand Bmid‐RT) or without (nomograms Abaselineand Bbaseline) PT response. Internal validation revealed good performance of these nomograms in discrimination: C‐statistics = 0.761 for nomogram Amid‐RTand 0.809 for nomogram Bmid‐RT, which showed better discrimination performance than (C‐statistics: 0.755) nomogram Abaselineand (C‐statistics: 0.798) nomogram Bbaseline(Z‐statistic = 2.476,p< 0.05; Z‐statistic = 1.971,p< 0.05).ConclusionThe nomograms based on PT response at mid‐RT showed favorable predictive accuracy for DFS and OS in patients with LA‐NPC.