Verbal memory impairment in congestive heart failure
Verbal memory impairment in congestive heart failure
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DOI：
10.1076/jcen.25.1.14.13635
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发表时间：
2003-02-01
影响因子：
2.2
通讯作者：
Rengo, F
中科院分区：
文献类型：
--
作者：
Incalzi, RA;Trojano, L;Rengo, F
认知功能障碍，主要是记忆障碍，是充血性心力衰竭（CHF）的特征。本研究的目的是验证：（1）CHF 对初级记忆和次级记忆有不同的影响； (2)记忆功能障碍可以通过筛查仪进行诊断。在一项多中心研究中，我们招募了 369 名稳定型 CHF 患者，他们接受了言语记忆机制和选定认知功能的结构化评估。一些言语记忆指数（新近度、Rey 的即时和延迟回忆、学习效率）的表现从纽约心脏协会 (NYHA) 的 II 级到 IV 级逐渐下降。 NYHA II-IV 级的遗忘率普遍较高。语言记忆指数与大多数非语言分数高度相关。简易精神状态检查（MMSE）相对于原发性或继发性言语记忆功能障碍的敏感性和特异性较差。因此，初级和次级记忆缺陷在CHF中相对常见，但不能通过筛查神经心理学测试准确识别。
Cognitive dysfunction, mainly memory impairment, characterizes congestive heart failure (CHF). Aim of this study was to verify whether: (1) CHF has differential effects on primary and secondary memory; (2) memory dysfunction can be diagnosed by a screening instrument. In a multicenter study we enrolled 369 patients with stable CHF who underwent a structured assessment of verbal memory mechanisms and selected cognitive functions.Performance on some verbal memory indexes (Recency, Rey's immediate and delayed recall, Learning efficiency) progressively decreased from II to IV New York Heart Association (NYHA) class. Rate of forgetting was uniformly high across NYHA classes II-IV. Verbal memory indexes were highly correlated with most nonverbal scores. The Mini Mental State Examination (MMSE) had poor sensitivity and specificity versus primary or secondary verbal memory dysfunction. Therefore, a deficit of both primary and secondary memory is relatively common in CHF but cannot be accurately recognized by a screening neuropsychological test.