NEUROFIBRILLARY TANGLES IN PROGRESSIVE SUPRANUCLEAR PALSY: ELECTRON MICROSCOPIC OBSERVATIONS
NEUROFIBRILLARY TANGLES IN PROGRESSIVE SUPRANUCLEAR PALSY: ELECTRON MICROSCOPIC OBSERVATIONS
复制标题
进行性核上性麻痹中的神经纤维缠结：电子显微镜观察
DOI：
10.1097/00005072-197401000-00007
复制
发表时间：
1974
影响因子：
3.2
通讯作者：
P. Lampert
中科院分区：
文献类型：
--
作者：
H. Powell;G. London;P. Lampert
临床和形态学研究结果进行性核上性麻痹PSP两例进行了讨论，并与观察脑炎后帕金森综合征。PSP患者最严重受累的脑区包括丘脑底核、前庭核和齿状核，以及通常与脑炎后帕金森综合征相关的脑区。在变性的神经元中发现了双棱神经纤维缠结。电子显微镜下可见变性神经元内的平野小体和电子致密的、膜结合的球状颗粒。神经纤维缠结由平行排列的直小管束交织而成。在这方面，PSP的神经元缠结不同于脑炎后帕金森综合征中由“扭曲的小管”组成的神经元缠结，也不同于实验诱导的由细丝组成的神经元缠结。
Clinical and morphologic findings from two patients with Progressive Supranuclear Palsy PSP are discussed and compared with observations in postencephalitic Parkinsonism. The most severely affected regions of the brain in PSP included the subthalamic, vestibular, and dentate nuclei in addition to those usually involved in postencephalitic Parkinsonism. Bircfringent neurofibrillary tangles were found in degenerating neurons. Electron microscopy showed juxtaneuronal Hirano bodies, and electron-dense, membrane-bound, spheroid particles within degenerating neurons. The neurofibrillary tangles were composed of interlacing bundles of straight tubules in parallel array. In this respect the neurofibrillary tangles of PSP differ from those in postencephalitic Parkinsonism, which consist of “twisted tubules”, and from experimentally induced neurofibrillary tangles, which are composed of filaments.