CLIP proteases and Plasmodium melanization in Anopheles gambiae
CLIP proteases and Plasmodium melanization in Anopheles gambiae
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DOI：
10.1016/j.pt.2007.05.001
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发表时间：
2007-07-01
影响因子：
9.6
通讯作者：
Barillas-Mury, Carolina
中科院分区：
文献类型：
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作者：
Barillas-Mury, Carolina
黑化是一种由酚氧化酶（PO）介导的有效免疫反应。多个CLIP -domain丝氨酸蛋白酶（CLIP）作为一个复杂的蛋白酶级联的一部分，调节PO的激活。几种CLIP作为冈比亚按蚊对伯氏疟原虫（小鼠疟疾）黑化反应的关键激活或抑制因子的作用最近已通过全基因组反向遗传学方法得到证实。在调控PO活化方面，安。冈比亚菌株也被鉴定出来。这篇综述总结了这些发现，并讨论了我们目前对An的理解。冈比亚黑化对疟原虫的反应。
Melanization is a potent immune response mediated by phenoloxidase (PO). Multiple Clip-domain serine proteases (CLIP) regulate PO activation as part of a complex cascade of proteases that are cleaved sequentially. The role of several CLIP as key activators or suppressors of the melanization responses of Anopheles gambiae to Plasmodium berghei (murine malaria) has been established recently using a genome-wide reverse genetics approach. Important differences in regulation of PO activation between An. gambiae strains were also identified. This review summarizes these findings and discusses our current understanding of the An. gambiae melanization responses to Plasmodium.