Second-Trimester Placental and Thyroid Hormones Are Associated With Cognitive Development From Ages 1 to 3 Years.
Second-Trimester Placental and Thyroid Hormones Are Associated With Cognitive Development From Ages 1 to 3 Years.
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DOI：
10.1210/jendso/bvab027
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发表时间：
2021-05-01
影响因子：
4.1
通讯作者：
Koistinen H
中科院分区：
文献类型：
--
作者：
Adibi JJ;Xun X;Zhao Y;Yin Q;LeWinn K;Bush NR;Panigrahy A;Peddada S;Alfthan H;Stenman UH;Tylavsky F;Koistinen H
充足的母体甲状腺激素（TH）对胎儿大脑发育是必要的。胎盘人绒毛膜促性腺激素（hCG）在确保TH产生中的作用还不太清楚。本研究的目的是评估1）胎盘hCG及其亚单位与孕中期母体TH的相关性，以及2）TH和胎盘激素对1岁和3岁时认知发育和交流的单一和联合作用。从田纳西州孟菲斯的CANDLE（影响神经认知发育和早期学习的疾病）妊娠队列中选择50例（5%）个体，招募时间为2006年至2011年，以平等代表男性和女性胎儿。参与者中有68%是黑人，32%是白色。测量的激素是母体血清（17-28周）中的母体甲状腺（促甲状腺激素[TSH]和游离甲状腺素[FT 4]）和胎盘激素（hCG、其高糖基化形式[hCG-h]和游离- [hCG]和-亚基[hCG]）。主要结果测量是婴儿和幼儿发展的贝利量表。所有形式的hCG与FT 4呈负相关，与TSH无关。hCG与1岁时的认知发育相关，并与TSH共同作用，预测3岁时的认知发育。这项初步研究增加了对hCG在孕中期促甲状腺作用的了解，以及这种机制对大脑发育的意义。需要更多的研究来阐明hCG、hCG和hCG-h之间在TH调节和儿童脑功能方面的差异。
Adequate maternal thyroid hormone (TH) is necessary for fetal brain development. The role of placental human chorionic gonadotropin (hCG) in ensuring the production of TH is less well understood. The objective of the study was to evaluate 1) associations of placental hCG and its subunits, and maternal TH in the second trimester, and 2) the single and joint effects of TH and placental hormones on cognitive development and communication at ages 1 and 3 years. Fifty individuals (5%) were selected from the CANDLE (Conditions Affecting Neurocognitive Development and Early Learning) pregnancy cohort in Memphis, Tennessee, with recruitment from 2006 to 2011, to equally represent male and female fetuses. Participants were 68% Black and 32% White. Hormones measured were maternal thyroid (thyrotropin [TSH] and free thyroxine [FT4]) and placental hormones (hCG, its hyperglycosylated form [hCG-h], and free - [hCG] and -subunits [hCG]) in maternal serum (17-28 weeks). The primary outcome measurement was the Bayley Scales of Infant and Toddler Development. All forms of hCG were negatively associated with FT4 and not associated with TSH. hCG was associated with cognitive development at age 1 year and jointly interacted with TSH to predict cognitive development at age 3 years. This pilot study added insight into the thyrotropic actions of hCG in the second trimester, and into the significance of this mechanism for brain development. More research is warranted to elucidate differences between hCG, hCG, and hCG-h in relation to TH regulation and child brain function.