Relationship between Ca2+ sparklets and sarcoplasmic reticulum Ca2+ load and release in rat cerebral arterial smooth muscle
Relationship between Ca2+ sparklets and sarcoplasmic reticulum Ca2+ load and release in rat cerebral arterial smooth muscle
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DOI：
10.1152/ajpheart.00488.2011
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发表时间：
2011-12-01
影响因子：
4.8
通讯作者：
Navedo, Manuel F.
中科院分区：
文献类型：
--
作者：
Takeda, Yukari;Nystoriak, Matthew A.;Navedo, Manuel F.
武田Y，Nystoriak MA，尼维斯-辛特龙M，桑塔纳LF，Navedo MF。大鼠脑动脉平滑肌钙离子与肌浆网钙负荷和释放的关系。Am J Physiol心脏圈Physiol 301：H2 285-H2 294,2011。首次发表于2011年10月7日；doi：10.1152/ajpheart.00488.2011。-Ca+Screlet是由肌膜L型钙通道开放产生的亚细胞钙信号。在动脉肌细胞的肌膜内，Ca~(2+)的Sparklet活性不同。在本研究中，我们研究了脑动脉肌细胞内钙离子火花活性与肌浆网(SR)内钙蓄积和释放的关系。我们的数据表明，SR是一个巨大的细胞器，在这些细胞的肌膜附近有多个区域。CA2+Sparklet站点位于或
Takeda Y, Nystoriak MA, Nieves-Cintron M, Santana LF, Navedo MF. Relationship between Ca2+ sparklets and sarcoplasmic reticulum Ca2+ load and release in rat cerebral arterial smooth muscle. Am J Physiol Heart Circ Physiol 301: H2285-H2294, 2011. First published October 7, 2011; doi:10.1152/ajpheart.00488.2011.-Ca+ sparklets are subcellular Ca2+ signals produced by the opening of sarcolemmal L-type Ca2+ channels. Ca2+ sparklet activity varies within the sarcolemma of arterial myocytes. In this study, we examined the relationship between Ca2+ sparklet activity and sarcoplasmic reticulum (SR) Ca2+ accumulation and release in cerebral arterial myocytes. Our data indicate that the SR is a vast organelle with multiple regions near the sarcolemma of these cells. Ca2+ sparklet sites were located at or