Genomic organization of mouse desmocollin genes reveals evolutionary conservation.
Genomic organization of mouse desmocollin genes reveals evolutionary conservation.
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小鼠桥粒胶蛋白基因的基因组组织揭示了进化保守性。
DOI：
10.1080/10425170410001679156
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Christiano,AngelaM
中科院分区：
文献类型：
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作者：
Kljuic,Ana;Bauer,RobertC;Christiano,AngelaM
桥粒钙粘蛋白是参与桥粒形成的钙调节蛋白家族，桥粒是一种对维持细胞粘附和组织稳定性很重要的细胞连接类型。桥粒斑块由桥粒钙粘蛋白、斑蛋白和犰狳蛋白家族的成员组成。桥粒钙粘蛋白是跨膜糖蛋白，通过其胞外重复结构域与相邻细胞的桥粒钙粘蛋白相互作用，并分为两个亚家族：桥粒芯糖蛋白 (Dsg) 和桥粒胶蛋白 (Dsc)。在细胞质侧，钙粘蛋白通过与斑蛋白和犰狳蛋白相互作用间接连接到中间丝 (IF) 网络。在这里，我们报告了两个小鼠桥粒胶蛋白基因 Dsc2 和 Dsc3 的基因组结构的阐明。有趣的是，在基因组水平上，桥粒芯蛋白显示出与经典钙粘蛋白（例如E-钙粘蛋白）比桥粒芯蛋白更高程度的相似性。
Desmosomal cadherins are a family of calcium regulated proteins involved in the formation of desmosomes, a type of cell junction important in maintaining cell adhesion and tissue stability. The desmosomal plaque consists of members of the desmosomal cadherin, plakin and armadillo family of proteins. Desmosomal cadherins are transmembrane glycoproteins that interact with desmosomal cadherins of the adjacent cells via their extracellular repeat domains and are divided in two subfamilies, the desmogleins (Dsg) and the desmocollins (Dsc). On the cytoplasmic side, the cadherins connect to the intermediate filament (IF) network indirectly by interacting with plakin and armadillo proteins. Here, we report the elucidation of the genomic structure of two mouse desmocollin genes,Dsc2andDsc3. Interestingly, at the genomic level, desmocollins show a higher degree of similarity to the classical cadherins, such as E-cadherin, than to the desmogleins.