Progesterone regulation of uterine dendritic cell function in rodents is dependent on the stage of estrous cycle
Progesterone regulation of uterine dendritic cell function in rodents is dependent on the stage of estrous cycle
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DOI：
10.1038/mi.2010.28
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发表时间：
2010-09-01
影响因子：
8
通讯作者：
Sternberg, E. M.
中科院分区：
文献类型：
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作者：
Butts, C. L.;Candando, K. M.;Sternberg, E. M.
类固醇激素，如黄体酮，能够调节免疫力，影响疾病结局。树突状细胞(DC)驱动强大的免疫反应，表达类固醇激素受体，在生殖道(包括子宫组织)感染期间可能是类固醇激素作用的主要靶点。在这里，我们报道了孕酮限制了DC相关激活标志的表达，并抑制了子宫DC分泌细胞因子，这与信号转导和转录激活因子1(STAT1)活性的变化有关。我们还发现，无论是在体外还是在体内，孕酮浓度较高的阶段(间情期、动情期)的小鼠DC对孕酮的敏感性高于孕酮浓度较低的阶段(动情期、动情期)。这种差异与DC表达的孕激素受体水平有关。这些数据表明，孕酮调节DC功能，并可能导致女性在整个生命周期的选定时间段对子宫和其他生殖道感染的易感性。
Steroid hormones, such as progesterone, are able to modify immunity and influence disease outcome. Dendritic cells (DCs) drive potent immune responses, express receptors for steroid hormones, and may be a primary target of steroid hormone actions during infection of the genital tract, including uterine tissue. Here, we report that progesterone limited DC-associated activation marker expression and inhibited cytokine secretion by uterine DCs, which was associated with changes in signal transducer and activator of transcription 1 (STAT1) activity. We also found that DCs from mice at stages with higher progesterone concentrations (diestrus, metaestrus) were more sensitive to progesterone than those in stages with lower progesterone concentrations (proestrus, estrus), both in vitro and in vivo. This difference correlated with the levels of progesterone receptor expressed by DCs. These data suggest that progesterone regulates DC function and could contribute to the susceptibility of females to uterine and other genital tract infections at selected time periods throughout the life cycle.