Alcohol-induced heart rate response dampening during aversive and rewarding stress paradigms in subjects at risk for alcoholism
Alcohol-induced heart rate response dampening during aversive and rewarding stress paradigms in subjects at risk for alcoholism
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DOI：
10.1016/j.ijpsycho.2005.10.016
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发表时间：
2006-08-01
影响因子：
3
通讯作者：
Olbrich, Robert
中科院分区：
文献类型：
--
作者：
Croissant, Bernhard;Rist, Fred;Olbrich, Robert
有酗酒家族史(FH+)的个人有发展成酒精问题的风险。在几项研究中，FH+受试者的心理生理应激反应比FH受试者中的酒精更弱。然而，从这些研究中尚不清楚，酒精(SRD)对FH+受试者的这种更强的应激反应抑制效应是否仅限于厌恶刺激，或者是否也适用于非厌恶应激条件。此外，男性和女性FH+受试者对酒精挑战的反应似乎不同，但很少在SRD范式中进行直接比较。参与者是54名女性和63名男性健康成年人：31名女性是酗酒父亲的女儿(DOA)，40名男性是儿子(SOA)。其余23名女性(DONA)和23名男性(SONA)没有任何酒精使用障碍。参与者参加了两个实验室会议，一个是有酒精的，另一个是没有酒精的。在每一次会议中，介绍了三种应激源程序。心率是这份报告中的主要因变量。SONA而不是SONA表现出向SRD发展的趋势。在女性参与者中，发生了强烈的SRD，但与我们的预期相反，只有在对照组。厌恶者的应激反应和SRD效应略强于奖励性任务。酒精诱发SRD的程度受BAL和无酒精条件下应激反应的幅度的强烈影响(多元回归分析)。因此，厌恶任务可能比奖励任务具有更强的应激反应，从而为观察FH和FH受试者在酒精诱导的SRD方面的差异提供了更好的条件。(C)2005 Elsevier B.V.保留所有权利。
Individuals with a family history of alcoholism (FH+) are at risk to develop alcohol problems. In several studies, psychophysiological stress responses were more attenuated by alcohol in FH+ than in FH- subjects. However, it is not clear from these studies, if this stronger stress-response dampening effect of alcohol (SRD) in FH+ subjects is confined to aversive stimuli, or would hold for nonaversive stress conditions as well. Also, male and female FH+ subjects seem to respond differently to the alcohol challenge, but have rarely been directly compared in a SRD paradigm. Participants were 54 female and 63 male healthy adults: 31 women were daughters (DOAs) and 40 men were sons (SOAs) of alcohol-dependent fathers. The remaining 23 women (DONAs) and 23 men (SONAs) had no FH of any alcohol use disorder. The participants took part in two laboratory sessions, one with and one without alcohol. In each session, three stressor procedures were presented. Heart rate is the main dependent variable in this report. SOAs, but not SONAs showed a tendency towards SRD. Among female participants, a strong SRD occurred, but contrary to our expectation only in controls. Stress responses and SRD effects were somewhat stronger in the aversive than in the rewarding task. The extent of alcohol induced SRD was strongly influenced by BAL and the amplitude of the stress response in the no-alcohol condition (multiple regression analysis). Thus, aversive tasks might have the advantage of eliciting stronger stress responses than rewarding tasks, thereby providing better conditions for observing differences in alcohol induced SRD between FH- and FH- subjects. (c) 2005 Elsevier B.V. All rights reserved.