Age-related deterioration of ability of acquisition in memory and learning in senescence accelerated mouse: SAM-P/8 as an animal model of disturbances in recent memory
Age-related deterioration of ability of acquisition in memory and learning in senescence accelerated mouse: SAM-P/8 as an animal model of disturbances in recent memory
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DOI：
10.1016/0006-8993(88)90671-3
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发表时间：
1988-11
期刊：
影响因子：
2.9
通讯作者：
H. Yagi;Seika Katoh;I. Akiguchi;T. Takeda
中科院分区：
文献类型：
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作者：
H. Yagi;Seika Katoh;I. Akiguchi;T. Takeda
采用被动回避反应T型迷宫和旷场实验研究了快速老化小鼠（SAM P/8）的学习记忆和行为学，并与抗衰老小鼠（SAM R/1）进行了比较。SAM-P/8小鼠在被动回避反应中的记忆和学习能力表现出与年龄相关的显着下降。这种与年龄相关的记忆和学习缺陷与获得能力的恶化有关，而不是由于在开放视野中观察到的保持能力和多动能力受损。在交替T-迷宫测试中，SAM-P/8显示出与SAM-R/1一样高的能力，在T-迷宫回避测试中，SAM-P/8也显示出与SAM-R/1一样完整的记忆能力，尽管在被动回避反应中存在记忆缺陷。因此，SAM-P/8可能被证明是一个相关的模型，用于研究老年人记忆缺陷的相关机制。
Memory, learning and behavior of senescence accelerated mouse (SAM-P/8) were investigated by using passive avoidance response T-maze and open field and the findings were compared with those from senescence resistant mouse (SAM-R/1 control). SAM-P/8 mice showed a remarkable age-related deterioration in ability of memory and learning in passive avoidance response. This age-related memory and learning deficit was linked to a deterioration in the ability of acquisition and was not due to impairment in the ability of retention and hyperactivity, as observed in the open field. In the alternation T-maze tests, SAM-P/8 showed as high ability as seen in the SAM-R/1 as did the SAM-R/1 and in the T-maze avoidance tests, SAM-P/8 also showed as intact a memory ability as seen in the SAM-R/1, despite a memory deficit in the passive avoidance response. Thus, SAM-P/8 may prove to be a pertinent model for researching mechanisms related to the memory deficit seen in senile humans.