Epstein-Barr virus-associated familial Hodgkin lymphoma: paediatric onset in three of five siblings
Epstein-Barr virus-associated familial Hodgkin lymphoma: paediatric onset in three of five siblings
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DOI：
10.1111/j.1365-2141.2005.05499.x
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发表时间：
2005-06-01
影响因子：
6.5
通讯作者：
d'Amore, F
中科院分区：
文献类型：
--
作者：
Kamper, PM;Kjeldsen, E;d'Amore, F
我们报告家族性霍奇金淋巴瘤（FHL）在一个家庭的五个孩子，其中三个是人类白细胞抗原（HLA）I类相同。这三个兄弟姐妹在6年内被诊断为EB病毒（EBV）阳性霍奇金淋巴瘤。所有三人都接受了化疗和/或放疗，目前完全缓解。没有一个孩子有明显的免疫缺陷或自身免疫性疾病的证据。这种情况下，有助于现有的材料FHL，并意味着HLA I类抗原和EB病毒感染的肿瘤细胞群在某些情况下FHL的发病机制的作用。
We report familial Hodgkin lymphoma (FHL) in a family with five children, of which three were human leucocyte antigen (HLA) class I identical. These three siblings were diagnosed with Epstein-Barr virus (EBV)-positive Hodgkin lymphoma within a 6-year period. All three were treated with chemo- and/or radiotherapy and are presently in complete remission. None of the children had evidence of overt immunodeficiency or autoimmune disease. This case contributes to the existing material on FHL and implies a role for both HLA class I antigens and EBV infection of the tumour cell population in the pathogenesis of some cases of FHL.