Quaternary Ammonium Salt Based NIR-II Probes for In Vivo Imaging
Quaternary Ammonium Salt Based NIR-II Probes for In Vivo Imaging
复制标题
用于体内成像的基于季铵盐的 NIR-II 探针
DOI：
10.1002/adom.201900229
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发表时间：
2019-08-01
影响因子：
9
通讯作者：
Hong, Xuechuan
中科院分区：
文献类型：
--
作者：
Qu, Chunrong;Xiao, Yuling;Hong, Xuechuan
Traditional luminescent materials including fluorescent probes suffer from notorious aggregation-caused quenching in aqueous solutions. Although several approaches such as the aggregation-induced emission effect have been developed, it remains a significant challenge to identify an effective and efficient strategy to resolve this issue. Herein, quaternary ammonium salts Q8PBn and Q8PNap as a novel class of bright near infrared window II (NIR-II, 1000-1700 nm) probes are designed and synthesized, and the twisted intramolecular charge transfer formation at the excited state can be effectively suppressed for the newly designed probes. Furthermore, Q8PNap complexation with fetal bovine serum (Q8PNap/FBS) significantly increases the quantum yield by approximate to 32-fold compared with PEGylated tertiary amine Q8P, and Q8PNap/FBS is successfully used to achieve high spatial and temporal resolution imaging of hind limb vasculature, lymphatic system, and small tumor metastasis, as well as precise NIR-II imaging-guided tumor and lymph node surgery in small animal models for the first time.
