Improvement on the Performance of Bone Regeneration of Calcium Sulfate Hemihydrate by Adding Mineralized Collagen
Improvement on the Performance of Bone Regeneration of Calcium Sulfate Hemihydrate by Adding Mineralized Collagen
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添加矿化胶原蛋白改善半水硫酸钙骨再生性能
DOI：
10.1089/ten.tea.2009.0669
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发表时间：
2010-06-01
影响因子：
4.1
通讯作者：
Cui, Fu-Zhai
中科院分区：
文献类型：
--
作者：
Liu, Huan-Ye;Liu, Xi;Cui, Fu-Zhai
本文报道了半水硫酸钙（CaSO_4中心点1/2 H（2）O; CSH）单独和CSH与矿化胶原的骨再生性能的比较研究。矿化胶原蛋白是纳米羟基磷灰石/胶原蛋白（nHAC）。研究内容包括体外生物相容性和体内骨修复性能。对骨基质干细胞进行定量和定性生物相容性测定。采用兔下颌骨临界盒状缺损模型，评价CSH和nHAC/CSH的骨改建能力。体外实验结果表明，与CSH相比，nHAC/CSH的生物活性明显提高，尤其是在促进细胞粘附方面。此外，nHAC/CSH复合材料周围的骨重建活性高于CSH，特别是在重建的早期阶段。这一结果意味着nHAC/CSH可能比仅CSH更早地促进骨修复和更好的骨整合。
Comparative investigations of bone regeneration performance for calcium sulfate hemihydrate (CaSO4 center dot 1/2H(2)O; CSH) only and CSH with mineralized collagen are reported in this article. The mineralized collagen is the nanohydroxyapatite/collagen (nHAC). The investigations included biocompatibility in vitro and performance of bone repair in vivo. Quantitative and qualitative biocompatibility assays with bone stromal stem cells were performed. A critical box-shaped defect model in the mandible of the rabbit was used to evaluate the bone-remodeling ability of CSH and nHAC/CSH. Results in vitro indicated that the nHAC/CSH significantly improved bioactivity compared with that of CSH, especially in promoting cell adhesion. Further, a higher bone remodeling activity was observed around nHAC/CSH composite than the CSH, especially at the early stage of remodeling. This result means that nHAC/CSH could cause an earlier accelerator and better osseointegration for bone repair than CSH only.