Methamphetamine abuse as a barrier to HIV medication adherence among gay and bisexual men
Methamphetamine abuse as a barrier to HIV medication adherence among gay and bisexual men
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DOI：
10.1080/09540120310001618621
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发表时间：
2003-12-01
影响因子：
1.7
通讯作者：
Shoptaw, S
中科院分区：
文献类型：
--
作者：
Reback, CJ;Larkins, S;Shoptaw, S
艾滋病毒感染者坚持服药很重要，这不仅是因为不坚持服药对个人健康的影响，而且还因为不坚持服药可能导致抗药性病毒株。然而，由于复杂的给药方案和副作用，坚持使用艾滋病毒药物是困难的。本文是一个定性分析艾滋病毒药物治疗依从性的男同性恋和双性恋的甲基苯丙胺滥用男性参加门诊药物治疗研究项目。作为开放式半结构化访谈的一部分，23名艾滋病毒感染者讨论了甲基苯丙胺使用对其药物依从性的影响。药物使用依从性障碍分为两个主题：（1）计划内不依从和（2）计划外不依从。有计划的不依从是应对艾滋病毒药物治疗时间表要求高的一种策略，或者与使用甲基苯丙胺时的性行为有关，或者与担心甲基苯丙胺与艾滋病毒药物混合产生相互作用有关。参与者没有将他们的药物治疗方案调整定义为不依从，而是作为一种实现对生活控制感的方式。计划外的不依从与甲基苯丙胺相关的食物和睡眠时间表中断有关。研究结果有助于为这一人群设计具有文化特异性的艾滋病毒药物依从性干预措施。
Medication adherence among persons with HIV infection is important not only because of the effect of non-adherence on an individual's health but also because non-adherence can lead to medication-resistant viral strains. However, adherence to HIV medications is difficult due to complex dosing regimens and side effects. This paper is a qualitative analysis of HIV medication adherence among gay and bisexual methamphetamine-abusing men enrolled in an outpatient drug treatment research project. As part of an open-ended, semi-structured interview, 23 HIV-infected men discussed the effects of their methamphetamine use on their medication adherence. Substance-use barriers to adherence were coded into two main themes: (1) planned non-adherence and (2) unplanned non-adherence. Planned non-adherence was a strategy for coping with demanding HIV medication schedules, or was linked to sexual behaviours while using methamphetamine or to fears of interaction effects from mixing methamphetamine with HIV medications. Participants did not define their medication regimen adjustments as non-adherence but as a way to achieve a sense of control over their lives. Unplanned non-adherence was linked to methamphetamine-related disruptions in food and sleep schedules. Findings are helpful in designing culturally specific HIV medication adherence interventions for this population.