Performance study of microfluidic devices for blood plasma separation—a designer’s perspective
Performance study of microfluidic devices for blood plasma separation—a designer’s perspective
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DOI：
10.1088/0960-1317/25/8/084004
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发表时间：
2015-07
影响因子：
2.3
通讯作者：
S. Tripathi;Y V Bala Varun Kumar;A. Prabhakar;S. S. Joshi-S.;A. Agrawal
中科院分区：
文献类型：
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作者：
S. Tripathi;Y V Bala Varun Kumar;A. Prabhakar;S. S. Joshi-S.;A. Agrawal
本文对各种基于流体动力流动分离技术的血浆微装置进行了设计和实验。我们研究了它们的性能作为依赖的控制参数的函数，如流速、饲料红细胞压积和微通道几何形状。这项工作的重点是理解简单几何中的分离现象；随后，单个简单的几何参数和生物物理效应相结合，制造杂交设计，导致更高的分离效率。我们的微流体装置的独特之处在于它们采用高尺寸（数百微米的顺序），因此可以在足够的持续时间内连续运行而不会堵塞，而制造的简单性使它们具有成本效益。该微型装置已在整个血细胞比容范围内（即从Hct 7%到Hct 45%）进行了实验验证。最佳混合设计对纯血的分离效率约为（78.34±2.7）%。我们相信，本研究提出的理论和实验结果将有助于在血浆分离微装置领域工作的设计者和研究人员。
In this work, design and experiments on various blood plasma microdevices based on hydrodynamic flow separation techniques is carried out. We study their performance as a function of dependent governing parameters such as flow rate, feed hematocrit, and microchannel geometry. This work focuses on understanding separation phenomena in simple geometries; subsequently, individual simple geometrical parameters and biophysical effects are combined to fabricate hybridized designs, resulting in higher separation efficiencies. The distinctive features of our microfluidic devices are that they employ elevated dimensions (of the order of hundreds of microns), and thereby can be operated continuously over sufficient duration without clogging, while simplicity of fabrication makes them cost effective. The microdevices have been experimentally demonstrated over the entire range of hematocrit (i.e. from Hct 7% to Hct 45%). A high separation efficiency of about (78.34 ± 2.7)% with pure blood is achieved in our best hybrid design. We believe that the theory and experimental results presented in this study will aid designers and researchers working in the field of blood plasma separation microdevices.