HIV and the risk of tuberculosis due to recent transmission over 12 years in Karonga District, Malawi
HIV and the risk of tuberculosis due to recent transmission over 12 years in Karonga District, Malawi
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DOI：
10.1016/j.trstmh.2009.03.013
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发表时间：
2009-12-01
影响因子：
2.2
通讯作者：
Glynn, Judith R.
中科院分区：
文献类型：
--
作者：
Houben, Rein M. G. J.;Crampin, Amelia C.;Glynn, Judith R.
结核病患者的菌株与其他近期病例相同(“聚集性”)，表明是近期传播的。艾滋病毒状况和年龄可能会影响聚集的比例。在马拉维的一项以人口为基础的研究中，我们根据艾滋病毒和年龄调查了结核病聚集性。在746例患者中，HIV感染增多的比例呈聚集性。在15-25岁、25-50岁和50岁之间，性别调整后的优势比分别为1.26(95%可信区间0.4-4.1)、1.40(0.9-2.3)和10.44(2.3-47.9)，并且在研究的两个时期内保持稳定。这些结果表明，由于最近在老年人中的传播，艾滋病毒增加了结核病的比例。(C)2009年皇家热带医学和卫生学会。爱思唯尔有限公司出版。保留所有权利。
Tuberculosis (TB) patients with strains common to other recent cases ('clustering') suggest recent transmission. HIV status and age may affect proportions clustered. We investigated TB clustering by HIV and age in a population-based study in Malawi. Among 746 patients, HIV infection increased the proportion clustered. Sex-period-adjusted odds ratios for the association of HIV and clustering were 1.26 (95% CI 0.4-4.1) for ages 15-25 years, 1.40 (0.9-2.3) for 25-50 years and 10.44 (2.3-47.9) for >50 years and remained stable over two periods examined. These results suggest that HIV increases the proportion of TB due to recent transmission in the elderly. (C) 2009 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.