The LRRK2-macroautophagy axis and its relevance to Parkinson's disease.
The LRRK2-macroautophagy axis and its relevance to Parkinson's disease.
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DOI：
10.1042/bst20160265
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发表时间：
2017-02-08
影响因子：
3.9
通讯作者：
Manzoni C
中科院分区：
文献类型：
--
作者：
Manzoni C
多年来，各种不同的功能和令人印象深刻的相互作用物阵列与富含亮氨酸的重复序列激酶2（LRRK 2）相关。在这里，我讨论了LRRK 2可能能够在不同的时间和地点与不同的蛋白质相互作用的假设，因此，基于形成的不同复合物控制了过多的不同功能。其中，我将集中在宏观自噬的一般情况下的内溶酶体系统。首先，将评估自噬在帕金森病中的相关性，简要概述所有相关的帕金森病基因;然后，将基于支持文献分析LRRK 2与巨自噬和内溶酶体途径的关联。
A wide variety of different functions and an impressive array of interactors have been associated with leucine-rich repeat kinase 2 (LRRK2) over the years. Here, I discuss the hypothesis that LRRK2 may be capable of interacting with different proteins at different times and places, therefore, controlling a plethora of diverse functions based on the different complexes formed. Among these, I will then focus on macroautophagy in the general context of the endolysosomal system. First, the relevance of autophagy in Parkinson's disease will be evaluated giving a brief overview of all the relevant Parkinson's disease genes; then, the association of LRRK2 with macroautophagy and the endolysosomal pathway will be analyzed based on the supporting literature.