Studies on the in vitro microenvironment in man.
Studies on the in vitro microenvironment in man.
复制标题
人体体外微环境的研究。
DOI：
10.1007/978-3-642-68761-7_67
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Keating,A
中科院分区：
文献类型：
--
作者：
Singer,JW;Keating,A
The recent adaptation of the murine long-term marrow culture system to humans by Gartner and Kaplan [1] has, for the first time, allowed an examination of the characteristics of those cells that form the in vitro, and possibly the in vivo, microenvironment. Both the human and the murine long-term marrow cultures develop characteristic adherent stromal cell layers that consist of cells described by Dexter as “endothelial-like, fat-containing cells and macrophages” [2]. Until recently, only descriptive information was available about marrow stromal cells (MSC) that are required for the support of in vitro hematopoiesis, We have initiated a series of studies to examine certain properties of MSC and their precursors, These studies suggest that MSC are derived from a transplantable stem cell that is multipotent for other hematopoietic elements. However, MSC also share characteristics with mesenchymal cells previously thought to be unrelated to hematopoietic lineages.
