Skeletal blood flow in Paget's disease of bone and its response to calcitonin therapy.
Skeletal blood flow in Paget's disease of bone and its response to calcitonin therapy.
复制标题
佩吉特骨病中的骨骼血流及其对降钙素治疗的反应。
DOI：
10.1042/cs0540069
复制
发表时间：
1978
期刊：
影响因子：
--
通讯作者：
M. Tellez
中科院分区：
文献类型：
--
作者：
Richard Wootton;J. Reeve;E. Spellacy;M. Tellez
1. Blood flow to the skeleton was measured by the 18F clearance method of Wooton, Reeve & Veall (1976) in 24 patients with untreated Paget's disease. In every patient but one, resting skeletal blood flow was increased. There was a significant positive correlation between skeletal blood flow and serum alkaline phosphatase and between skeletal blood flow and urinary total hydroxyproline excretion. 2. Fourteen patients were re-studied after they had received short-term (7 days or less) or long-term (7 weeks or more) calcitonin. Skeletal blood flow, alkaline phosphatase and urinary hydroxy-proline excretion fell towards normal in every case. There was some evidence from the short-term studies that calcitonin produced a more rapid fall in skeletal blood flow than in alkaline phosphatase. 3. Glomerular filtration rate appeared to increase transiently in response to calcitonin.
