In vivo EPR tooth dosimetry for triage after a radiation event involving large populations
In vivo EPR tooth dosimetry for triage after a radiation event involving large populations
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DOI：
10.1007/s00411-014-0534-9
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发表时间：
2014-05-01
影响因子：
1.7
通讯作者：
Swartz, Harold M.
中科院分区：
文献类型：
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作者：
Williams, Benjamin B.;Flood, Ann Barry;Swartz, Harold M.
灾难性事件后，大量人员可能受到危及生命的电离辐射剂量，对辐射损伤的管理将主要依赖于合适的生物剂量测定方法的可用性和使用。体内电子顺磁共振 (EPR) 牙齿剂量测定具有许多有价值且独特的特性和功能，可能有助于实现有效的分类。我们已经生产了可展开 EPR 牙齿剂量计的原型，并在多项体外和体内研究中对其进行了测试，以表征最先进的性能和实用性。本报告重点介绍了该技术的最新进展，这些进展加强了证据，证明体内 EPR 牙齿剂量测定可以在其预期用途的背景下提供实用、准确和快速的测量，以帮助在简易核装置事件中对受害者进行分类。这些进展证明该信号稳定、精确度在 0.5 Gy 以内，并且可以在体内成功进行。测量全牙辐射诱导 EPR 信号随时间的稳定性，以确认其长期稳定性并更好地表征辐射后数小时内的信号行为。对安装在简单解剖口腔模型内的五对天然人类上中切牙进行剂量测定，该模型展示了实现 0.5 Gy 逆剂量预测标准误差的能力。对未暴露于显着水平电离辐射的志愿者受试者和作为骨髓移植手术一部分接受全身照射的患者进行了使用完整上切牙进行剂量估计和筛查的评估。根据这些和之前对体内牙齿剂量测定系统的性能和使用的评估，得出的结论是，该系统可能是帮助管理大规模放射事件的非常有价值的资源。
The management of radiation injuries following a catastrophic event where large numbers of people may have been exposed to life-threatening doses of ionizing radiation will rely critically on the availability and use of suitable biodosimetry methods. In vivo electron paramagnetic resonance (EPR) tooth dosimetry has a number of valuable and unique characteristics and capabilities that may help enable effective triage. We have produced a prototype of a deployable EPR tooth dosimeter and tested it in several in vitro and in vivo studies to characterize the performance and utility at the state of the art. This report focuses on recent advances in the technology, which strengthen the evidence that in vivo EPR tooth dosimetry can provide practical, accurate, and rapid measurements in the context of its intended use to help triage victims in the event of an improvised nuclear device. These advances provide evidence that the signal is stable, accurate to within 0.5 Gy, and can be successfully carried out in vivo. The stability over time of the radiation-induced EPR signal from whole teeth was measured to confirm its long-term stability and better characterize signal behavior in the hours following irradiation. Dosimetry measurements were taken for five pairs of natural human upper central incisors mounted within a simple anatomic mouth model that demonstrates the ability to achieve 0.5 Gy standard error of inverse dose prediction. An assessment of the use of intact upper incisors for dose estimation and screening was performed with volunteer subjects who have not been exposed to significant levels of ionizing radiation and patients who have undergone total body irradiation as part of bone marrow transplant procedures. Based on these and previous evaluations of the performance and use of the in vivo tooth dosimetry system, it is concluded that this system could be a very valuable resource to aid in the management of a massive radiological event.