Sociocultural and Dietary Practices Among Malay Subjects in the North-Eastern Region of Peninsular Malaysia: A Region of Low Prevalence of Helicobacter pylori Infection
Sociocultural and Dietary Practices Among Malay Subjects in the North-Eastern Region of Peninsular Malaysia: A Region of Low Prevalence of Helicobacter pylori Infection
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DOI：
10.1111/j.1523-5378.2011.00917.x
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发表时间：
2012-02-01
期刊：
影响因子：
4.4
通讯作者：
Graham, David Y.
中科院分区：
文献类型：
--
作者：
Lee, Yeong Yeh;Ismail, Ahmad Wazi;Graham, David Y.
背景和目的：在马来西亚半岛东北部地区的马来人中，幽门螺杆菌感染的流行率特别低。原因不明。我们的目的是比较不同的环境因素与H。pylori在出生和居住在吉兰丹的马来人中的患病率。方法：在2000年至2008年期间接受上消化道内窥镜检查的吉兰丹马来人中进行病例对照研究。幽门螺杆菌状态通过胃组织学确定。社会文化和饮食因素进行了评估，使用2008年后管理的有效的问卷调查，并使用logistic回归分析的数据进行了分析。pylori阳性和82个对照）。单变量分析确定了五个不良的卫生习惯与H。幽门螺杆菌感染：使用井水、使用坑式厕所、不经常煮沸饮用水、如厕后和饭前不经常洗手。多因素Logistic回归分析发现三个变量与H.幽门螺杆菌感染：经常喝茶（OR：0.023，95%CI：0.01-0.07），经常使用“布渡”或当地的调味酱料（OR：0.09，95% CI：0.1-0.7），以及频繁使用“pegaga”或Centenella asiatica结论：在卫生、社会文化和饮食习惯多年来没有改变的假设下，我们可以得出结论，H.幽门螺杆菌与不卫生的做法有关，而保护则与饮用茶和当地生产的食品“pegaga”和“budu”有关。这些饮食因素是未来研究对H。幽门螺杆菌传播。
Background and Aim: The prevalence of Helicobacter pylori infection is exceptionally low among the Malays in the north-eastern region of Peninsular Malaysia. The reasons are unknown. Our aim was to compare environmental factors that differed in relation to H. pylori prevalence among Malays born and residing in Kelantan.Methods: A case-control study was conducted among Malays in Kelantan who underwent upper endoscopy between 2000 and 2008. Helicobacter pylori status was determined by gastric histology. Sociocultural and dietary factors were assessed using a validated investigator-directed questionnaire administered after 2008, and the data were analyzed using logistic regression analysis.Results: The study group consisted of 161 subjects ( 79 H. pylori positive and 82 controls). Univariable analysis identified five poor sanitary practices associated with an increased prevalence of H. pylori infection: use of well water, use of pit latrine, less frequent boiling of drinking water, and infrequent hand wash practice after toilet use and before meals. Multivariable logistic regression analysis identified three variables inversely associated with H. pylori infection: frequent consumption of tea ( OR: 0.023, 95% CI: 0.01-0.07), frequent use of "budu'' or local anchovy sauce ( OR: 0.09, 95% CI: 0.1-0.7), and frequent use of "pegaga'' or centenella asiatica ( OR: 0.25, 95% CI: 0.1-0.65).Conclusions: Under the assumption that sanitary, sociocultural, and dietary habits have not changed over the years, we can conclude that an increased risk of H. pylori was associated with unsanitary practices whereas protection was associated with consumption of tea and locally produced foods, "pegaga'' and "budu.'' These dietary factors are candidates for future study on the effects on H. pylori transmission.