Continuous theta burst stimulation over left supplementary motor area facilitates auditory-vocal integration in individuals with Parkinson's disease.
Continuous theta burst stimulation over left supplementary motor area facilitates auditory-vocal integration in individuals with Parkinson's disease.
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DOI：
10.3389/fnagi.2022.948696
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发表时间：
2022
影响因子：
4.8
通讯作者：
中科院分区：
文献类型：
--
作者：
越来越多的证据表明，以听觉反馈扰动异常增强的声音补偿为特征的听觉-声音整合障碍导致帕金森病（PD）的运动功能减退性构音障碍。然而，这种异常的治疗仍然是一个挑战。本研究旨在探讨PD患者的音高调节的神经-运动整合异常是否可以通过神经导航的左侧辅助运动区（SMA）的连续θ爆发刺激（c-TBS）进行调制。在左侧SMA上接受主动或假c-TBS后，16名PD患者在听到自己的声音时发出元音，同时意外地向上或向下移动了两个元音。一组配对的健康参与者被招募作为对照。测量并比较了不同条件下他们的声音反应和事件相关电位（ERPs）。结果表明，在PD患者中，在左侧SMA上应用c-TBS导致较小的发声反应，由较小的P1和P2反应和较大的N1反应所取代。减少P2反应的主要神经发生器位于右额下回和内侧回，中央前回和中央后回，和小脑。P2波幅降低和N1波幅增强可预测抑制性发声补偿。值得注意的是，与健康对照相比，PD患者异常增强的声音和P2反应通过c-TBS而正常化，超过左侧SMA。我们的研究结果提供了第一个因果关系的证据表明，在帕金森病的音高产生的神经运动控制异常可以调制的c-TBS在左SMA，这表明它可能是一个有前途的非侵入性治疗帕金森病的言语运动障碍。
Accumulating evidence suggests that impairment in auditory-vocal integration characterized by abnormally enhanced vocal compensations for auditory feedback perturbations contributes to hypokinetic dysarthria in Parkinson’s disease (PD). However, treatment of this abnormality remains a challenge. The present study examined whether abnormalities in auditory-motor integration for vocal pitch regulation in PD can be modulated by neuronavigated continuous theta burst stimulation (c-TBS) over the left supplementary motor area (SMA). After receiving active or sham c-TBS over left SMA, 16 individuals with PD vocalized vowel sounds while hearing their own voice unexpectedly pitch-shifted two semitones upward or downward. A group of pairwise-matched healthy participants was recruited as controls. Their vocal responses and event-related potentials (ERPs) were measured and compared across the conditions. The results showed that applying c-TBS over left SMA led to smaller vocal responses paralleled by smaller P1 and P2 responses and larger N1 responses in individuals with PD. Major neural generators of reduced P2 responses were located in the right inferior and medial frontal gyrus, pre- and post-central gyrus, and insula. Moreover, suppressed vocal compensations were predicted by reduced P2 amplitudes and enhanced N1 amplitudes. Notably, abnormally enhanced vocal and P2 responses in individuals with PD were normalized by c-TBS over left SMA when compared to healthy controls. Our results provide the first causal evidence that abnormalities in auditory-motor control of vocal pitch production in PD can be modulated by c-TBS over left SMA, suggesting that it may be a promising non-invasive treatment for speech motor disorders in PD.
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影响因子：
1.7
作者：
Chait, M;Simon, JZ;Poeppel, D
通讯作者：
Poeppel, D
影响因子：
5.7
作者：
Behroozmand R;Shebek R;Hansen DR;Oya H;Robin DA;Howard MA 3rd;Greenlee JD
通讯作者：
Greenlee JD
影响因子：
2.4
作者：
Burnett, TA;Freedland, MB;Hain, TC
通讯作者：
Hain, TC
DOI：
10.1016/j.nicl.2013.10.016
发表时间：
2014
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Arnold C;Gehrig J;Gispert S;Seifried C;Kell CA
通讯作者：
Kell CA
DOI：
10.1016/j.clinph.2012.01.010
发表时间：
2012-05
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Groppa S;Oliviero A;Eisen A;Quartarone A;Cohen LG;Mall V;Kaelin-Lang A;Mima T;Rossi S;Thickbroom GW;Rossini PM;Ziemann U;Valls-Solé J;Siebner HR
通讯作者：
Siebner HR