Nonantioxidant functions of α-tocopherol in smooth muscle cells
Nonantioxidant functions of α-tocopherol in smooth muscle cells
复制标题
DOI：
10.1093/jn/131.2.378s
复制
发表时间：
2001-02-01
影响因子：
4.2
通讯作者：
Zingg, JM
中科院分区：
文献类型：
--
作者：
Azzi, A;Breyer, I;Zingg, JM
除α-生育酚外，大多数生育酚和生育三烯酚不被人体保留。这表明α-生育酚是唯一识别的;因此，它可能发挥排他性功能。α-生育酚具有独立于其促氧化剂、抗氧化剂或自由基清除能力的独特性质。α-生育酚特异性抑制蛋白激酶C、某些细胞的生长和CD 36酸性胶原酶基因的转录。在蛋白磷酸酶2A（PP（2）A）和其他基因（α-原肌球蛋白和结缔组织生长因子）的表达上也观察到激活事件。无论是β-生育酚还是普罗布考都不具有与α-生育酚相同的特殊功能。最近，我们分离到一种新的普遍存在的胞浆α-生育酚结合蛋白（TAP）.它的基序表明它是疏水配体结合蛋白家族（CRAL-TRIO）的成员。TAP还可能参与细胞α-生育酚浓度和α-生育酚介导的信号传导的调节。
Most tocopherols and tocotrienols, with the exception of alpha -tocopherol, are not retained by humans. This suggests that alpha -tocopherol is recognized uniquely; therefore, it may exert an exclusive function. alpha -Tocopherol possesses distinct properties that are independent of its prooxidant, antioxidant or radical-scavenging ability. alpha -Tocopherol specifically inhibits protein kinase C, the growth of certain cells and the transcription of the CD36 acid collagenase genes. Activation events have also been seen on the protein phosphatase 2A (PP(2)A) and on the expression of other genes (alpha -tropomyosin and connective tissue growth factor). Neither beta -tocopherol nor probucol possessed the same specialty functions as alpha -tocopherol. Recently, we isolated a new ubiquitous cytosolic alpha -tocopherol binding protein (TAP). Its motifs suggest that it is a member of the hydrophobic ligand-binding protein family (CRAL-TRIO). TAP may also be involved in the regulation of cellular alpha -tocopherol concentration and alpha -tocopherol-mediated signaling.