THE EFFECT OF DIETARY SEAWEEDS ON 7,12-DIMETHYL-BENZ[A]ANTHRACENE-INDUCED MAMMARY TUMORIGENESIS IN RATS
THE EFFECT OF DIETARY SEAWEEDS ON 7,12-DIMETHYL-BENZ[A]ANTHRACENE-INDUCED MAMMARY TUMORIGENESIS IN RATS
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DOI：
10.1016/0304-3835(87)90033-4
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发表时间：
1987-05-01
期刊：
影响因子：
9.7
通讯作者：
MORIGUCHI, M
中科院分区：
文献类型：
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作者：
YAMAMOTO, I;MARUYAMA, H;MORIGUCHI, M
六组雌性大鼠喂食含有2%的六种粉末海藻之一的饮食152天，并连续59或60天喂食基础饮食，对照组在整个实验期间喂食基础饮食。对所有大鼠灌胃给予7，12-二甲基苯并[a]蒽（20 mg/kg × 10 - 6）。1）、开始饲喂后27天。3周龄的饲料中，分别添加了紫菜（Porphyra tenera，PT）、海带（Laminaria religiosa，LR）和海带（L.日本变种ochotensis（LO）对乳腺肿瘤的发生具有抑制作用。肿瘤发生率分别为35%（7/20）、35%（7/20）和50%（9/18），而对照组为69%（20/29）。LR组和PT组大鼠首次触及肿瘤的时间显著延迟（P < 0.01）。对于各组中每只大鼠的肿瘤重量，LR喂养组中的肿瘤重量为1.6g，与对照组中的16.3g相比显著降低（P < 0.02）。
Six groups of female rats were fed diets containing 2% of one of six powdered seaweeds for 152 days and a basic diet for 59 or 60 successive days, and controls were fed the basic diet for the whole experimental period. The 7,12-dimethylbenz[a]anthracene was given to all rats intragastrically (20 mg/kg .times. 1), 27 days after the start of feeding. Diets with 3 weeks, Porphyra tenera (PT), Laminaria religiosa (LR) and L. japonica var. ochotensis (LO), showed an inhibitory effect on mammary tumorigenesis. Tumor incidences were 35% (7/20), 35% (7/20) and 50% (9/18), respectively, whereas that in the control group was 69% (20/29). There was a significant delay in the time to first palpable tumor in LR-fed and PT-fed rats (P < 0.01). As for the tumor weight per rat in each group, it was significantly lower in the LR-fed group with a weight of 1.6 g, as compared with that of 16.3 g in the control group (P < 0.02).