Restriction of amino acids extends lifespan in Drosophila melanogaster
Restriction of amino acids extends lifespan in Drosophila melanogaster
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DOI：
10.1016/j.mad.2006.02.005
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发表时间：
2006-07-01
影响因子：
5.3
通讯作者：
Tatar, Marc
中科院分区：
文献类型：
--
作者：
Min, Kyung-Jin;Tatar, Marc
饮食限制延长了成年果蝇的寿命，当饮食酵母的浓度在含有丰富碳水化合物的介质中稀释时。在这里，我们改变酪蛋白作为成人饮食中氨基酸来源的浓度，以揭示负责长寿控制的营养酵母的质量。在饮食中加入中等水平的酪蛋白，可以最大限度地延长寿命。存活率的差异不是由年龄无关死亡率的升高引起的；中级酪蛋白的最长寿命不会出现，因为酪蛋白在较高浓度时是非特异性有害的。此外，当饮食中酪蛋白水平提高时，繁殖力也会增加。维持在中等酪蛋白水平的成年果蝇的人口学表型类似于它们对有限饮食酵母的反应。通过稀释酵母来限制饮食可能会延长寿命，因为这限制了氨基酸的摄入量。(C)2006爱思唯尔爱尔兰有限公司。保留所有权利。
Dietary restriction extends adult Drosophila melanogaster life span when the concentration of dietary yeast is diluted in a media with abundant carbohydrates. Here we vary the concentration of casein as a source of amino acids in adult diet to uncover a quality of nutrient yeast responsible for longevity control. Longevity is maximized upon diet with intermediary levels of casein. Differences in survival are not caused by elevated age-independent mortality; the longevity maximum at intermediate casein does not arise because casein is non-specifically harmful at higher concentrations. Furthermore, fecundity increases when the level of dietary casein is elevated. The demographic phenotypes of adult Drosophila maintained on intermediate levels of casein resemble their response to limited dietary yeast. Dietary restriction through dilution of yeast may extend longevity because this limits the intake of amino acids. (c) 2006 Elsevier Ireland Ltd. All rights reserved.