Effects of Colistin on the Sensory Nerve Conduction Velocity and F-wave in Mice
Effects of Colistin on the Sensory Nerve Conduction Velocity and F-wave in Mice
复制标题
粘菌素对小鼠感觉神经传导速度和F波的影响
DOI：
10.1111/bcpt.12272
复制
发表时间：
2014-12-01
影响因子：
3.1
通讯作者：
Xiao, Xilong
中科院分区：
文献类型：
--
作者：
Dai, Chongshan;Tang, Shusheng;Xiao, Xilong
本研究的目的是利用小鼠模型检测感觉神经传导速度（SNCV）和F波在粘菌素诱导的周围神经毒性中的变化。小鼠通过3分钟静脉输注给予粘菌素5、7.5和15 mg/kg/天。采用双极记录电极测量感觉神经传导速度（SNCV）和F波。SNCV和F波潜伏期呈剂量和时间依赖性变化。F波潜伏期在第3天显著延长，SNCV在第3天显著降低（P
The aim of this study was to examine the changes of sensory nerve conduction velocity (SNCV) and F-wave for colistin-induced peripheral neurotoxicity using a mouse model. Mice were administered with colistin 5, 7.5 and 15mg/kg/day via a 3-min. intravenous infusion. The sensory nerve conduction velocity (SNCV) and F-wave were measured using the bipolar recording electrodes. The SNCV and F-wave latency changed in a dose- and time-dependent manner. The significant increase of F-wave latency and significant decrease of SNCV appeared on day 3 (p