Body mass index in early and middle-late adulthood and risk of localised, advanced and fatal prostate cancer: a population-based prospective study.
Body mass index in early and middle-late adulthood and risk of localised, advanced and fatal prostate cancer: a population-based prospective study.
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DOI：
10.1038/bjc.2011.319
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发表时间：
2011-09-27
影响因子：
8.8
通讯作者：
Wolk, A.
中科院分区：
文献类型：
--
作者：
Discacciati, A.;Orsini, N.;Andersson, S-O;Andren, O.;Johansson, J-E;Wolk, A.
成年早期和中晚期的体重指数（BMI）与前列腺癌（PCa）发病率（按疾病亚型（局部、晚期）和致死性PCa）之间的关系尚不清楚。从1998年1月至2008年12月，对36959名45-79岁瑞典男性的PCa发病率（1530例局部和554例晚期病例被诊断）和PCa死亡率（225例致死性病例）进行了随访。根据竞争风险分析，观察到局部PCa的发生率与基线时的BMI呈负相关（成年中后期;与22 kg m-2相比，35 kg m-2的率比（RR）为0.69（95% CI 0.52-0.92）），但在30岁时并非如此。对于致死性PCa，基线时BMI与无统计学意义的风险增加相关（每增加5个单位的RR：1.12（0.88-1.43）），30岁时BMI与风险降低相关（每增加5个单位的RR：0.72（0.51-1.01））。我们的研究结果表明，在中晚期肥胖，但不是成年早期，和本地PCa之间的负相关。他们还表明BMI和致命PCa之间存在双重关联-在成年早期肥胖的男性中风险降低，而在成年中后期肥胖的男性中风险增加。
The relationships between body mass index (BMI) during early and middle-late adulthood and incidence of prostate cancer (PCa) by subtype of the disease (localised, advanced) and fatal PCa is unclear. A population-based cohort of 36 959 Swedish men aged 45–79 years was followed up from January 1998 through December 2008 for incidence of PCa (1530 localised and 554 advanced cases were diagnosed) and through December 2007 for PCa mortality (225 fatal cases). From a competing-risks analysis, incidence of localised PCa was observed to be inversely associated with BMI at baseline (middle-late adulthood; rate ratio (RR) for 35 kg m–2 when compared with 22 kg m–2 was 0.69 (95% CI 0.52–0.92)), but not at age 30. For fatal PCa, BMI at baseline was associated with a nonstatistically significant increased risk (RR for every five-unit increase: 1.12 (0.88–1.43)) and BMI at age 30 with a decreased risk (RR for every five-unit increase: 0.72 (0.51–1.01)). Our results indicate an inverse association between obesity during middle-late, but not early adulthood, and localised PCa. They also suggest a dual association between BMI and fatal PCa – a decreased risk among men who were obese during early adulthood and an increased risk among those who were obese during middle-late adulthood.
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