Network Systems Biology for Drug Discovery
Network Systems Biology for Drug Discovery
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DOI：
10.1038/clpt.2010.91
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发表时间：
2010-07-01
影响因子：
6.7
通讯作者：
Terzic, A.
中科院分区：
文献类型：
--
作者：
Arrell, D. K.;Terzic, A.
系统生物学为整合健康和疾病中的细胞、器官和生物体过程中的多个组成部分和相互作用提供了一个平台。除了关注单个分子或途径的传统方法外，对高通量数据集的生物信息网络分析提供了整合生物复杂性和多层次连接的机会。在合理的药物发现中的新兴应用范围从针对和模拟疾病破坏的网络，到筛选化学或配位体文库，到识别/验证药物-靶相互作用以提高疗效和安全性。
Systems biology provides a platform for integrating multiple components and interactions underlying cell, organ, and organism processes in health and disease. Beyond traditional approaches focused on individual molecules or pathways, bioinformatic network analysis of high-throughput data sets offers an opportunity for integration of biological complexity and multilevel connectivity. Emerging applications in rational drug discovery range from targeting and modeling disease-corrupted networks to screening chemical or ligand libraries to identification/validation of drug-target interactions for improved efficacy and safety.