Epidemiological study of primary intracranial tumors: a regional survey in Kumamoto prefecture in southern Japan-20-year study
Epidemiological study of primary intracranial tumors: a regional survey in Kumamoto prefecture in southern Japan-20-year study
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DOI：
10.1007/s10147-010-0178-y
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发表时间：
2011-08-01
影响因子：
3.3
通讯作者：
Kuratsu, Jun-ichi
中科院分区：
文献类型：
--
作者：
Nakamura, Hideo;Makino, Keishi;Kuratsu, Jun-ichi
背景随着神经影像学技术的广泛应用以及各种环境因素的影响，颅内肿瘤的发病率和类型比例发生了变化。然而，在日本还没有关于颅内肿瘤的准确的基于人群的流行病学研究报告。我们评估了最近的发展趋势，在发生原发性颅内肿瘤的居民之间的熊本prefecture，Japanes.Methods和结果我们调查了5,448例新的原发性颅内肿瘤的诊断，在熊本县之间的1989年和2008年。经年龄调整的总发病率为每年每10万人口14.09人（男性11.59人，女性16.38人）。最常见的肿瘤是脑膜瘤（36.8%），其次是胶质瘤（19.5%）、腺瘤（17.8%）、神经鞘瘤（9.9%）和恶性淋巴瘤（3.6%）。老年人原发性脑肿瘤，特别是脑膜瘤和恶性胶质瘤的病例数稳步增加，无症状颅内肿瘤的发病率也有所增加。1997年至2008年期间，每年诊断出的无症状脑膜瘤数量高于有症状脑膜瘤。此外，熊本县的脑淋巴瘤发病率正在接近西方国家的记录。另一方面，生殖细胞肿瘤的发病率呈下降趋势，已接近西方国家儿童的发病率。结论虽然我们根据日本人口调整了熊本县的人口，但几种颅内肿瘤的发病率仍呈上升趋势。这些发病率正在接近西方国家。
Background The increased use of neuro-imaging techniques, as well as various environmental factors, has been changing the incidence and the proportions of types of intracranial tumors. However, no accurate population-based epidemiological study of intracranial tumors in Japan has been reported. We evaluated recent trends in the occurrence of primary intracranial tumors among residents of Kumamoto prefecture, Japan.Methods and results We surveyed 5,448 new cases of primary intracranial tumors that were diagnosed in Kumamoto prefecture between 1989 and 2008. The overall age-adjusted incidence rate was 14.09 (11.59 for males, 16.38 for females) per 100,000 population per year. The most common tumors were meningiomas (36.8%), followed by gliomas (19.5%), adenomas (17.8%), schwannomas (9.9%), and malignant lymphomas (3.6%). The number of cases of primary brain tumors, especially meningiomas and malignant gliomas, among the elderly has steadily increased and the incidence of asymptomatic intracranial tumors also increased. The number of asymptomatic meningiomas diagnosed per year was higher than that of symptomatic meningiomas in the years between 1997 and 2008. Furthermore, the incidence rate of brain lymphoma in Kumamoto prefecture is approaching that recorded in Western countries. On the other hand, the incidence rate of germ cell tumors is on the decline, approaching that recorded for children in Western countries.Conclusion Even though we adjusted the population in Kumamoto prefecture based on the Japanese population, increasing rates of several types of intracranial tumors were observed. These incidence rates are approaching those in Western countries.