Endogenous ouabain, sodium balance and blood pressure.
Endogenous ouabain, sodium balance and blood pressure.
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内源性哇巴因、钠平衡和血压。
DOI：
10.1097/00004872-199602000-00003
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发表时间：
1996
影响因子：
4.9
通讯作者：
M. Nicholls
中科院分区：
文献类型：
--
作者：
G. Pidgeon;L. Lewis;T. Yandle;A. Richards;M. Nicholls
Hamyln等人的综述收集的信息表明，肾上腺分泌瓦巴因（或密切相关的异构体），在健康受试者中以纳摩尔水平在血浆中循环，在血压紊乱或体液和电解质平衡紊乱的患者中以更高的浓度循环。作者注意到，在大鼠身上进行的实验表明，长期服用瓦巴因可诱发高血压。基于这一证据，Hamlyn等人提出瓦巴因（或其异构体）可能有助于动脉压的长期调节。他们还认为，无论是遗传性的还是后天的，肾排泄瓦巴因缺陷都可能导致某些原发性高血压患者循环瓦巴因水平升高，并诱发或促成高血压bbb的发展。
The review of Hamyln et al collects information suggesting that the adrenal glands secrete ouabain (or a closely related isomer), which circulates in plasma at nanomolar levels in healthy subjects and at higher concentrations in patients with disorders of blood pressure or fluid and electrolyte balance [1]. The authors note experiments in rats showing that chronic ouabain administration can induce hypertension. Based on this evidence, Hamlyn et al. propose that ouabain (or an isomer of it) might contribute to the long-term regulation of arterial pressure [1]. They suggest also that defects in the renal excretion of ouabain, whether inherited or acquired, may account for raised circulating ouabain levels in certain patients with essential hypertension and induce, or contribute to, the development of their hypertension [1].