Levels of brain related proteins in cerebrospinal fluid: An aid in the differential diagnosis of parkinsonian disorders
Levels of brain related proteins in cerebrospinal fluid: An aid in the differential diagnosis of parkinsonian disorders
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DOI：
10.1016/j.parkreldis.2008.05.001
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发表时间：
2009-03-01
影响因子：
4.1
通讯作者：
Rosengren, Lars
中科院分区：
文献类型：
--
作者：
Constantinescu, Radu;Zetterberg, Henrik;Rosengren, Lars
帕金森病（PD）、多系统萎缩（MSA）、进行性核上性麻痹（PSP）和皮质基底变性（CBD）等帕金森病是一大群常见的神经退行性疾病。最初的鉴别诊断可能极具挑战性，对预后有重大影响。淀粉样蛋白- β (A β 42)、神经丝轻链（NFL）、神经丝重链（pNFH）、tall蛋白、胶质纤维酸性蛋白（GFAP）、神经元特异性烯醇化酶（NSE）、S-10013蛋白和髓鞘碱性蛋白（MBP）等42个氨基酸片段是存在于神经元和胶质细胞中的脑相关蛋白（BRP）。在多种神经系统疾病（包括帕金森病）引起脑组织损伤后，它们被释放到脑脊液（CSF）中。文献回顾表明，仔细解释，脑脊液BRP水平可以在帕金森病的鉴别诊断中有价值。(C) 2008 Elsevier Ltd版权所有。
Parkinsonian disorders Such as Parkinson's disease (PD), Multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and cortico-basal degeneration (CBD), are a large group of common neurodegenerative diseases. The initial differential diagnosis can be extremely challenging with major implications for prognosis. The 42 amino acid fragment of amyloid-beta (A beta 42), neurofilament light chain (NFL), neurofilament heavy chain (pNFH), tall protein, glial fibrillary acidic protein (GFAP), neuron specific enolase (NSE), S-10013 protein, and myelin basic protein (MBP) are brain related proteins (BRP) present in neurons and glia cells. They are released in the cerebrospinal fluid (CSF) after brain tissue damage caused by a variety of neurological diseases, including the parkinsonian disorders. A review of the literature shows that, carefully interpreted, the CSF levels of BRP can be Of value in the differential diagnosis of parkinsonian disorders. (C) 2008 Elsevier Ltd. All rights reserved.