DIM mitigates the development of experimental autoimmune encephalomyelitis by maintaining the stability and suppressive function of regulatory T cells
DIM mitigates the development of experimental autoimmune encephalomyelitis by maintaining the stability and suppressive function of regulatory T cells
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DOI：
10.1016/j.cellimm.2020.104238
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发表时间：
2020-12-01
影响因子：
4.3
通讯作者：
Peng, Zhongxing
中科院分区：
文献类型：
--
作者：
Yang, Sujuan;Tan, Lixi;Peng, Zhongxing
最近的研究表明，吲哚是芳香烃受体(AhR)的饮食配体，在多种自身免疫性疾病中具有平衡调节性T细胞(Tregs)和Th17细胞分化的免疫调节特性。在本研究中，我们旨在探讨吲哚3，3‘-二吲哚甲烷(DIM)在实验性自身免疫性脑脊髓炎(EAE)中对Tregs稳定性和抑制功能的影响。此外，我们使用AhR拮抗剂CH223191验证了DIM通过激活AhR而对Tregs发挥作用。我们发现DIM通过维持Tregs的稳定和抑制功能而不是促进Tregs的分化来显著减轻EAE的严重程度。因此，这些经Dim处理的Treg可能间接抑制Th17细胞的产生和促炎细胞因子的产生。我们的研究进一步探讨了膳食吲哚促进EAE模型中Treg活性的机制。DIM可能作为一种新的治疗方法来抑制多发性硬化症的自身免疫性炎症。
Recent studies have revealed that indoles, dietary ligands of the aryl hydrocarbon receptor (AhR), have immunomodulatory characteristics of balancing the differentiation of regulatory T cells (Tregs) and Th17 cells in multiple autoimmune diseases.In this study, we aimed to investigate the potency of the indole, 3,3'-diindolylmethane (DIM), on the stability and suppressive function of Tregs in experimental autoimmune encephalomyelitis (EAE). Furthermore, we used the AhR antagonist CH223191 to verify that DIM exerts its effects on Tregs through the activation of AhR.We found that DIM treatment significantly alleviated the severity of EAE by maintaining the stability and suppressive function of Tregs instead of facilitating the differentiation of Tregs. Thus, these DIM-treated Tregs might indirectly inhibit the generation of Th17 cells and the production of proinflammatory cytokines. And we confirmed the critical role of AhR in the EAE model.Our study further investigated the mechanisms by which dietary indoles promote Treg activity in the EAE model. DIM may act as a novel therapeutic to restrain autoimmune inflammation in multiple sclerosis.