Sex-specific and race/ethnicity-specific disparities in cholangiocarcinoma incidence and prevalence in the USA: An updated analysis of the 2000-2011 Surveillance, Epidemiology and End Results registry
Sex-specific and race/ethnicity-specific disparities in cholangiocarcinoma incidence and prevalence in the USA: An updated analysis of the 2000-2011 Surveillance, Epidemiology and End Results registry
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DOI：
10.1111/hepr.12605
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发表时间：
2016-06-01
影响因子：
4.2
通讯作者：
Wong, Robert J.
中科院分区：
文献类型：
--
作者：
Mosadeghi, Sasan;Liu, Benny;Wong, Robert J.
目的：胆管细胞癌（CCA）是一种少见但致命的恶性肿瘤，在世界范围内，肝内胆管细胞癌（ICC）的发病率不断增加，而肝外胆管细胞癌（ECC）的发病率却在下降。评估美国CCA发病率的年龄特异性、性别特异性、种族/民族特异性变化。方法：使用2000-2011年监测、流行病学和最终结果登记处的基于人群的癌症登记数据，我们回顾性评估了美国成人中按ICC和ECC亚型分层的CCA发病率和患病率的年龄特异性、性别特异性、种族/民族特异性变化。结果：共确定了11296例ICC患者和8672例ECC患者。ICC发病率明显高于ECC（1.6/10万/年比1.3/10万/年，P < 0.01）。在所有种族/族裔群体以及ICC和ECC中，亚洲人的癌症发病率最高。当按年龄分层时，CCA发病率在所有组中均随年龄增加;然而，亚洲人的发病率上升最快。例如，在80岁及以上的患者中，亚洲人的ICC发病率几乎是非西班牙裔白人的两倍（13.8 vs 7.2/100 000/年）。总体而言，男性CCA发病率高于女性，随着年龄的增长，这种性别差异更加明显。例如，在80岁及以上的患者中，ICC的发病率在男性中为9.8/100 000/year，在女性中为6.9/100 000/year。此外，男性和亚洲人的CCA发生率最高，存在性别特异性和种族/民族特异性差异。
Aim: Cholangiocarcinoma (CCA) is an uncommon but lethal malignancy with an increasing worldwide incidence of intrahepatic cholangiocarcinoma (ICC), but decreasing incidence of extrahepatic cholangiocarcinoma (ECC). To evaluate age-specific, sex-specific, race/ethnicity-specific variations in CCA incidence in the USA.Methods: Using population-based cancer registry data from the 2000-2011 Surveillance, Epidemiology and End Results registry, we retrospectively evaluated age-specific, sex-specific, race/ethnicity-specific variations in incidence and prevalence of CCA stratified by ICC and ECC subtypes among adults in the USA.Results: A total of 11 296 patients with ICC and 8672 patients with ECC were identified. ICC incidence was significantly higher than ECC incidence (1.6 vs 1.3 per 100 000/year, P < 0.01). Among all race/ethnic groups and among both ICC and ECC, Asians had the highest cancer incidence. When stratified by age, CCA incidence increased with age among all groups; however, the rising incidence was most rapid among Asians. For example, among patients aged 80 years and over, the incidence of ICC among Asians was nearly twice the incidence among non-Hispanic whites (13.8 vs 7.2 per 100 000/year). Overall, CCA incidence was higher among men compared with women, and with increasing age, this sex-specific disparity was more pronounced. For example, among patients aged 80 years and over, the incidence of ICC was 9.8 per 100 000/year among men and 6.9 per 100 000/year among women.Conclusion: Among adults with CCA in the USA, increasing age was associated with increasing incidence of CCA. In addition, sex-specific and race/ethnicity-specific disparities were seen with the highest incidence of CCA among men and among Asians.