Cytochrome P450-encoding genes from the Heliconius genome as candidates for cyanogenesis
Cytochrome P450-encoding genes from the Heliconius genome as candidates for cyanogenesis
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DOI：
10.1111/imb.12042
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发表时间：
2013-10-01
影响因子：
2.6
通讯作者：
Ffrench-Constant, R. H.
中科院分区：
文献类型：
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作者：
Chauhan, R.;Jones, R.;Ffrench-Constant, R. H.
细胞色素P450在异生物质的代谢和化合物如生氰葡萄糖苷的产生中都很重要，昆虫在防御中使用这些化合物。在本研究中，我们使用转录组和基因组信息分离和命名P450编码基因的蝴蝶Heliconius melpomene。我们将每个假定的基因分类到其相应的超家族中，并比较P450在测序昆虫中的分布。我们还确定了同源的两个P450已知参与蓝藻的六点伯内特蛾，Zygaena filiorae。HeliconiusP450的分类应该是解剖它们在开发其寄主植物西番莲中的作用的重要一步。
Cytochrome P450s are important both in the metabolism of xenobiotics and the production of compounds such as cyanogenic glucosides, which insects use in their defence. In the present study, we use transcriptomic and genomic information to isolate and name P450-encoding genes from the butterfly Heliconius melpomene. We classify each of the putative genes into its appropriate superfamily and compare the distribution of P450s across sequenced insects. We also identify homologues of two P450s known to be involved in cyanogenesis in the six-spot Burnet moth, Zygaena filipendulae. Classification of HeliconiusP450s should be an important step in the dissection of their role in the exploitation of their host plant, the passion vine Passiflora.