PHOSPHORYLATION AND ACTIVATION OF THE JAK-3 JANUS KINASE IN RESPONSE TO INTERLEUKIN-2
PHOSPHORYLATION AND ACTIVATION OF THE JAK-3 JANUS KINASE IN RESPONSE TO INTERLEUKIN-2
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DOI：
10.1038/370151a0
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发表时间：
1994-07-14
期刊：
影响因子：
64.8
通讯作者：
O'SHEA, JJ
中科院分区：
文献类型：
--
作者：
JOHNSTON, JA;KAWAMURA, M;O'SHEA, JJ
LUTERLEUKIN-2 是 T 细胞的自分泌生长因子 (1,2)，它还可以激活其他细胞，包括 B 细胞 (3) 和自然杀伤细胞 (4)。白细胞介素 2 受体 (IL-2R) 的亚基缺乏内在的酶活性，但蛋白质酪氨酸磷酸化是配体结合后的一个关键事件，并且已知 src 家族激酶（例如 Lck）会被 IL-2 激活（参考文献 5-9）。然而，IL-2 信号传导可以在没有与 Lck 受体相互作用的情况下发生，这表明其他蛋白酪氨酸激酶可能很重要(10)。在这里，我们报道了 Janus 激酶家族的一个新成员 (Jak-3) 与人外周血 T 细胞和自然杀伤细胞中的 IL-2R 偶联。
LUTERLEUKIN-2 is an autocrine growth factor for T cells(1,2) which also activates other cells including B cells(3) and natural killer cells(4). The subunits of the interleukin-2 receptor (IL-2R) lack intrinsic enzymatic activity, but protein tyrosine phosphorylation is a critical event following ligand binding and src family kinases, such as Lck, are known to be activated by IL-2 (refs 5-9). However, IL-2 signalling can occur in the absence of receptor interaction with Lck, suggesting that other protein tyrosine kinases might be important(10). Here we report that a new member of the Janus family of kinases (Jak-3) is coupled to the IL-2R in human peripheral blood T cells and natural killer cells.