Interaction between ethanol and dextroamphetamine: effects on psychomotor performance.
Interaction between ethanol and dextroamphetamine: effects on psychomotor performance.
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乙醇和右旋苯丙胺之间的相互作用：对精神运动表现的影响。
DOI：
10.1111/j.1530-0277.1992.tb00640.x
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Hicks,RE
中科院分区：
文献类型：
--
作者：
Perez-Reyes,M;White,WR;McDonald,SA;Hicks,RE
本研究的目的是探讨酒精和苯丙胺之间的相互作用，精神方面的表现。12名健康的男性有偿志愿者，中度使用乙醇和安非他明，参加了这项研究。在30分钟间隔内给予乙醇（0.85 g/kg或安慰剂）。在终止乙醇或安慰剂摄入前5分钟，给予在50 ml橙子汁中稀释的苯丙胺酏剂（0.09 mg/kg、0.18 mg/kg或安慰剂）。受试者在单盲、拉丁方、交叉设计中接受了以下六种条件的测试：安慰剂乙醇/安慰剂苯丙胺;安慰剂乙醇/低剂量苯丙胺;安慰剂乙醇/高剂量苯丙胺;乙醇/安慰剂苯丙胺;乙醇/低剂量苯丙胺;和乙醇/高剂量苯丙胺。在这项研究中测量的变量是：酒精和苯丙胺中毒的主观评级，准确性和药物损害的模拟器评估（SEDI任务）的反应潜伏期，血液酒精浓度的呼吸分析仪，和血浆浓度的苯丙胺的气相色谱法。结果表明，乙醇诱导的驾驶汽车所需技能的性能下降，以剂量反应的方式被苯丙胺显着降低。苯丙胺的管理并没有降低酒精中毒的主观评级。
The objective of this study was to investigate the interaction between ethanol and dextroamphetamine with regard to psychomotor performance. Twelve healthy, male, paid volunteers, moderate users of ethanol and amphetamines, participated in this study. Ethanol (0.85 g/kg or placebo) was administered over a 30‐min interval. Five minutes before the termination of ethanol or placebo ingestion, dextroamphetamine elixir (0.09 mg/kg, 0.18 mg/kg or placebo) diluted in 50 ml of orange juice was administered. Subjects were tested in a single‐blind, latin‐square, crossover design with each of the following six conditions: placebo ethanol/placebo dextroamphetamine; placebo ethanol/low‐dose dextroamphetamine; placebo ethanol/high‐dose dextroamphetamine; ethanol/placebo dextroamphetamine; ethanol/low‐dose dextroamphetamine; and ethanol/high‐dose dextroamphetamine. The variables measured in this study were: subjective rating of ethanol and dextroamphetamine intoxication, accuracy and latency of response in the Simulator Evaluation of Drug Impairment (SEDI task), blood ethanol concentration by breath analyzer, and plasma concentrations of dextroamphetamine by gas chromatography. Results indicate ethanol induced decrements in performance of the skills necessary to drive an automobile were significantly decreased by dextroamphetamine in a dose‐response fashion. The administration of dextroamphetamine did not decrease the subjective ratings of ethanol intoxication.