Expression of γ-H2AX in melanocytic lesions
Expression of γ-H2AX in melanocytic lesions
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DOI：
10.1016/j.humpath.2008.03.007
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发表时间：
2008-11-01
期刊：
影响因子：
3.3
通讯作者：
Ma, Linglei
中科院分区：
文献类型：
--
作者：
Wasco, Matthew J.;Pu, Robert T.;Ma, Linglei
γ-H2AX 是激活 DNA 损伤的标记物，在许多恶性肿瘤及其前体病变中过度表达。先前的研究已证明γ-H2AX在黑色素瘤和发育不良痣中表达，但其在各种黑色素细胞病变中的诊断和预后效用尚未得到充分研究。在当前的研究中，我们研究了总共 162 个黑素细胞病变中的 γ-H2AX 表达。我们发现，在原位黑色素瘤（12/13）、原发性皮肤黑色素瘤（32/33；去髓性黑色素瘤除外）和转移性黑色素瘤（58/62）中观察到较高水平的 γ-H2AX（染色百分比和染色强度），这与良性痣（7/9）、发育不良痣（6/10）和 Spitz 痣有统计学差异(5/9) 一起考虑 (P
gamma-H2AX is a marker of activated DNA damage and is overexpressed in many malignancies their precursor lesions. Previous studies have demonstrated the expression of gamma-H2AX in melanoma and dysplastic nevus, but its diagnostic and prognostic utility in a full range of melanocytic lesions has not been fully studied. In the Current study, we investigated gamma-H2AX expression in a total of 162 melanocytic lesions. We found that gamma-H2AX was observed at higher levels (percentage and intensity of staining) in melanoma in situ (12/13), primary cutaneous melanoma (32/33; with the exception of desitroplastic melanoma), and metastatic melanoma (58/62), which was statistically different from that in benign ncvus (7/9), dysplastic nevus (6/10), and Spitz nevus (5/9) considered together (P