Secondary Amine Formation from Reductive Amination of Carbonyl Compounds Promoted by Lewis Acid Using the InCl3/Et3SiH System
Secondary Amine Formation from Reductive Amination of Carbonyl Compounds Promoted by Lewis Acid Using the InCl3/Et3SiH System
复制标题
DOI：
10.1021/ol901111g
复制
发表时间：
2009-08-06
期刊：
影响因子：
5.2
通讯作者：
Yang, Dan
中科院分区：
文献类型：
--
作者：
Lee, On-Yi;Law, Ka-Lun;Yang, Dan
以Zn（ClO 4）（2）中心点6 H（2）O为催化剂，研究了伯胺与醛、酮的还原胺化反应。通过InCl 3和Et 3SiH的组合原位生成的[In-H]被用作有效的还原体系。一锅法可合成多种仲胺，产率高。
A robust and reliable method has been developed for reductive amination of primary amines with various aldehydes and ketones using Zn(ClO4)(2)center dot 6H(2)O as a catalyst. [In-H] generated in situ via a combination of InCl3 and Et3SiH is employed as an effective reducing system. A variety of secondary amines can be synthesized in a one-pot procedure in excellent yields.