USE OF L-ARGININE IN THE TREATMENT OF EXPERIMENTAL NECROTIZING ENTEROCOLITIS
USE OF L-ARGININE IN THE TREATMENT OF EXPERIMENTAL NECROTIZING ENTEROCOLITIS
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DOI：
10.1016/0022-3468(95)90567-7
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发表时间：
1995-02-01
影响因子：
2.4
通讯作者：
KRANTIS, A
中科院分区：
文献类型：
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作者：
DILORENZO, M;BASS, J;KRANTIS, A
虽然病因学是多因素的，但早产和喂养是与坏死性小肠结肠炎（NEC）相关的两个最常见的危险因素。为了了解NEC的发病机制，必须阐明未成熟人类肠道中肠内容物和清除机制之间的复杂相互作用。一氧化氮（NO）是一种非肾上腺素能非胆碱能神经抑制的介质，引起肠道松弛。除了作为神经效应物质的作用外，研究表明NO的内源性形成还可以维持肠粘膜的完整性，保护肠道免受血源性毒素和组织破坏性介质的影响。因此，NO在肠平滑肌松弛和粘膜保护中具有双重作用。由于NEC发展中的两个主要风险因素是早产（因为它与肠道动力障碍有关）和肠内喂养（因为它与管腔内基质引起的粘膜损伤有关），作者选择研究NO在新生仔猪管腔内注射酸化酪蛋白溶液诱导的NEC发病机制中的作用。研究方法：在用该模型（n = 32）在宏观上和组织学上证实了NEC的一致诱导后，进行了以下研究。新生仔猪（
Although multifactorial in etiology, prematurity and feeding are two of the most common risk factors associated with necrotizing enterocolitis (NEC). To understand the pathogenesis of NEC, the complex interaction between intestinal contents and clearing mechanisms in the immature human gut must be elucidated. Nitric oxide (NO) is a proposed mediator of nonadrenergic noncholinergic neural inhibition, causing relaxation in the gut. In addition to its role as a neuroeffector substance, studies suggest that endogenous formation of NO maintains intestinal mucosal integrity, protecting the gut from blood-borne toxins and tissue-destructive mediators. Thus, NO has a dual role in both gut smooth muscle relaxation and mucosal protection. Because two of the primary risk factors in the development of NEC are prematurity (as it relates to gut dysmotility) and enteral feeding (as it relates to mucosal damage by intraluminal substrate), the authors chose to investigate the role of NO in the pathogenesis of NEC induced by intraluminal injection of acidified casein solution in neonatal piglets. Methods: Having confirmed the consistent induction of NEC both macroscopically and histologically with this model (n = 32), the following were undertaken. Neonatal piglets (