AORTIC FUNCTION DURING NORMAL HUMAN-PREGNANCY
AORTIC FUNCTION DURING NORMAL HUMAN-PREGNANCY
复制标题
DOI：
10.1016/0002-9378(86)90477-1
复制
发表时间：
1986-04-01
影响因子：
9.8
通讯作者：
METCALFE, J
中科院分区：
文献类型：
--
作者：
HART, MV;MORTON, MJ;METCALFE, J
在正常妊娠和复杂妊娠中都观察到动脉破裂和夹层。为了了解动脉力学特性在怀孕期间可能发生的变化，我们通过m型超声心动图测量了主动脉根直径，并同时获得了静息和等长运动时收缩期和舒张期的袖带血压。19名妇女在正常妊娠结束时和产后3至6个月时进行了测量。在正常的人类怀孕期间，主动脉更大，更柔顺，这些变化可能不会恢复到怀孕前的水平。主动脉顺应性增加，血管阻力降低，可提高正常妊娠左心室功能。相反，假定的结构改变导致顺应性增加可能削弱病变血管，导致妊娠期间剥离或破裂。
Arterial rupture and dissection have been observed in both normal and complicated pregnancies. To understand how arterial mechanical properties might change during pregnancy, we measured aortic root diameter by M-mode echocardiography and obtained simultaneous cuff blood pressures during systole and diastole at rest and during isometric exercise. Measurements were obtained in 19 women at the end of normal gestation and again 3 to 6 months post partum. The aorta is larger and more compliant during normal human pregnancy, and these changes may not revert to prepregnant levels post partum. Increased aortic compliance, combined with decreased vascular resistance, may enhance left ventricular performance in normal pregnancy. Conversely, the presumed structural alterations leading to increased compliance may weaken diseased vessels leading to dissection or rupture during pregnancy.