Isoform-specific modulation of Na+, K+-ATPase alpha-subunit gene expression in hypertension.
Isoform-specific modulation of Na+, K+-ATPase alpha-subunit gene expression in hypertension.
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高血压中Na、K-ATP酶α亚基基因表达的亚型特异性调节。
DOI：
10.1126/science.2838907
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Ruiz-Opazo,N
中科院分区：
文献类型：
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作者：
Herrera,VL;Chobanian,AV;Ruiz-Opazo,N
钠、钾-腺苷三磷酸酶（Na+，K+-ATP酶）被假设通过其对平滑肌反应性和心肌收缩性的影响参与全身性血管性高血压。通过对两种高血压大鼠模型心脏、主动脉和骨骼肌RNA的RNA印迹分析，发现Na+，K+-ATP酶α亚基信使RNA亚型（α2和α3）对血管内压力的升高有去诱导作用。观察实验性高血压48小时或更长时间后的变化。在这些条件下，另一种α亚型（α1）和β亚基信使RNA的协同诱导，可能是对钠通量变化的反应，而不是对血压升高的反应。
Sodium, potassium-adenosine triphosphatase (Na+,K+-ATPase) is hypothesized to be involved in systemic vascular hypertension through its effects on smooth muscle reactivity and myocardial contractility. By means of RNA blot analyses of cardiac, aortic, and skeletal muscle RNAs in two rat hypertensive models, Na+,K+-ATPase α-subunit messenger RNA isoforms (α2 and α3) were shown to be deinduced in response to increased intravascular pressure. The changes were observed after 48 hours or more of experimental hypertension. Under these conditions, there is coordinate induction of another α isoform (α1) and of β-subunit messenger RNAs, probably in response to alterations in sodium flux rather than to elevated blood pressure.